4-(Methylsulfonyl)phenol

4-(Methylsulfonyl)phenol Basic information

Product Name:	4-(Methylsulfonyl)phenol
Synonyms:	4-(METHYLSULFONYL)PHENOL;4-METHYLSULPHONYLPHENOL;4-METHANESULFONYL-PHENOL;4-(methylsulfonyl)-pheno;4-Hydroxyphenyl methyl sulfone;4-hydroxyphenylmethylsulfone;p-(methylsulfonyl)-pheno;p-(Methylsulfonyl)phenol
CAS:	14763-60-1
MF:	C7H8O3S
MW:	172.2
EINECS:	632-596-9
Product Categories:
Mol File:	14763-60-1.mol

4-(Methylsulfonyl)phenol Chemical Properties

Melting point	90-95 °C
Boiling point	272.52°C (rough estimate)
density	1.3692 (rough estimate)
refractive index	1.5151 (estimate)
RTECS	SM1530000
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO, Methanol
form	Powder
pka	pK1:7.83 (25°C)
color	Tan to pink-brown
Water Solubility	slight
BRN	1866322
LogP	0.886 (est)
CAS DataBase Reference	14763-60-1(CAS DataBase Reference)
NIST Chemistry Reference	4-(Methylsulfonyl)phenol(14763-60-1)

Safety Information

Hazard Codes	Xi
Risk Statements	36
Safety Statements	24/25-26
WGK Germany	3
Hazard Note	Irritant
HS Code	29309090

MSDS Information

Provider	Language
4-Methylsulfonylphenol	English
ACROS	English

4-(Methylsulfonyl)phenol Usage And Synthesis

Chemical Properties	Tan to pink-brown powder
Uses	4-(Methylsulfonyl)phenol is a reagent in the synthesis of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists. Also a reagent in the synthesis of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators.
Reactions	The reaction of 4-(methylsulfonyl)phenol (17.2 g, 100.0 mmol) with p-Toluenesulfonic anhydride as outlined in the general procedure provided 4-(methylsulfonyl)phenyl 4-methylbenzenesulfonate (26.1 g, 81%).

4-(Methylsulfonyl)phenol Preparation Products And Raw materials

Raw materials	Sodium hydroxide-->Hydrochloric acid-->Ethyl acetate-->Acetic acid-->Chloroform-->Magnesium sulfate-->Hydrogen peroxide-->Carbon tetrachloride-->Acetyl chloride-->Sodium periodate-->4-(Methylthio)phenol
Preparation Products	2-BROMO-4-(METHYLSULFONYL)PHENOL-->1-(2-bromoethoxy)-4-(methylsulfonyl)benzene

4-(Methylsulfonyl)phenol P-FLUOROPHENYL-P-METHOXYPHENYL SULFONE AKOS BBS-00002840 4-((4-[(3-CHLORO-2,2-DIMETHYLPROPANOYL)OXY]-3,5-DIMETHYLPHENYL)SULFONYL)-2,6-DIMETHYLPHENYL 3-CHLORO-2,2-DIMETHYLPROPANOATE 4-(methylsulphonyl)-2-nitrophenol 4,4'-Sulphonylbis(2,6-dibromophenol) 3-AMINO-4-METHOXYPHENYL ETHYL SULFONE Bis(4-hydroxyphenyl) Sulfone REACTIVE VIOLET 5 2-PROPANONE, 1-[(4-METHOXYPHENYL)SULFONYL]- 4-METHOXYPHENYLMETHYLSULFONE ETHYL 2-[(4-METHOXYPHENYL)SULFONYL]ACETATE Bis[4-(4-aminophenoxy)phenyl]sulfone 4,4'-BIS(3-AMINOPHENOXY)DIPHENYL SULFONE BIS(4-HYDROXY-3,5-DIMETHYLPHENYL) SULFONE 2-AMINO-4-(ETHYLSULFONYL)PHENOL 3,3'-Diamino-4,4'-dihydroxydiphenyl sulfone

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