2-Chloropropane

2-Chloropropane Basic information
Product Name:2-Chloropropane
Synonyms:2-chloro-propan;2-chloropropane(isopropylchloride);2-Chlorpropan;2-Propyl chloride;2-Propylchloride;Chlorodimethylmethane;iso-C3H7Cl;Isoprid
CAS:75-29-6
MF:C3H7Cl
MW:78.54
EINECS:200-858-8
Product Categories:CHLORO ALKANE COMPOUNDS;Organics;Alkyl;Building Blocks;Chemical Synthesis;Halogenated Hydrocarbons;Organic Building Blocks;API Intermediate
Mol File:75-29-6.mol
2-Chloropropane Structure
2-Chloropropane Chemical Properties
Melting point -118 °C
Boiling point 35 °C
density 0.859 g/mL at 25 °C(lit.)
vapor pressure 28.11 psi ( 55 °C)
refractive index n20/D 1.395(lit.)
Fp −31 °F
storage temp. Store below +30°C.
solubility alcohol: miscible(lit.)
form clear liquid
color Colorless to Light yellow
explosive limit2.8-10.7%(V)
Water Solubility 3.1 g/L (20 ºC)
Merck 14,5211
BRN 1730782
Stability:Stable. Incompatible with strong oxidizing agents, strong bases. Highly flammable - note low flash point. Cool to zero C before opening.
CAS DataBase Reference75-29-6(CAS DataBase Reference)
NIST Chemistry ReferencePropane, 2-chloro-(75-29-6)
EPA Substance Registry System2-Chloropropane (75-29-6)
Safety Information
Hazard Codes F+,Xi,Xn,F
Risk Statements 12-36/37-20/21/22-11-40
Safety Statements 9-29-36-26-16
RIDADR UN 2456 3/PG 1
WGK Germany 3
RTECS UC7200000
10-23
Autoignition Temperature590 °C
TSCA Yes
HazardClass 3
PackingGroup I
HS Code 29031980
Hazardous Substances Data75-29-6(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rabbit > 2000 mg/kg
MSDS Information
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2-Chloropropane English
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2-Chloropropane Usage And Synthesis
Chemical PropertiesColourless liquid
Uses2-Chloropropane decomposes by first-order reaction to give hydrogen chloride and propylene. It is a short-chain chlorinated paraffins that is a component in lubricant additives, metal processing, leather fat-liquoring, plastics softening, PVC plasticizing, flame retardants in paints, adhesives and sealants. It shows anesthetic properties. Further, it is used as an alternative foam-blowing agent.
2-Chloropropane is used as a solvent and an intermediate.It can be used as a reactant:
In the Friedel-Crafts alkylation reaction of difluorobenzene and toluene using solid acid and methylalumoxane catalysts, respectively.
To prepare 4-amino-3-iodo-1-(isopropyl)pyrazolo[3,4-d]pyrimidine, a key intermediate for the synthesis of PfPK7 kinase inhibitors.
It is used to prepare benzylisopropylphenylphosphine and chlorodiethylisopropylsilane.
Uses2-Chloropropane is used as a solvent and an intermediate. It shows anesthetic properties. Further, it is used as an alternative foam-blowing agent. It is used to prepare chlorodiethylisopropylsilane.
General DescriptionA colorless liquid with a chloroform-like odor. Vapors heavier than air. Less dense than water. May irritate skin and eyes, and be narcotic in high concentrations. A fire and explosion risk. Used to make other chemicals.
Air & Water ReactionsHighly flammable. Slightly soluble in water.
Reactivity ProfileHalogenated aliphatic compounds, such as 2-Chloropropane, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Low molecular weight haloalkanes are highly flammable and can react with some metals to form dangerous products. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.
HazardHighly flammable, fire and explosion risk, explosive limits in air 2.8–10.7%.
Health HazardACUTE/CHRONIC HAZARDS: Fire hazard: Highly dangerous; when exposed to heat, flame or oxidizers. Explosion hazard: Moderate when exposed to heat or flame.
Fire HazardHIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Safety ProfileMutation data reported. A flammable liquid. A very dangerous fire hazard when exposed to heat, flame, or oxidners. When heated to decomposition it emits toxic fumes of Cl-. See also 1 CHLOROPROPANE.
Purification MethodsPurify the chloride with 95% H2SO4 as described for isopropyl bromide, then dry with MgSO4, P2O5 or CaH2, and fractionally distil it from Na2CO3 or CaH2. Alternatively, a stream of oxygen containing ca 5% ozone is passed through the chloride for about three times as long as is necessary to obtain the first coloration of starch iodide paper by the exit gas, and the liquid is then washed with NaHCO3 solution to hydrolyse ozonides and remove organic acids before drying and distilling. [Beilstein 1 IV 191.]
Methylene Chloride Promethazine hydrochloride 2,3-DICHLOROPROPIONYL CHLORIDE p-Aminobenzylchloride Propane 2,2-DICHLOROPROPANE Resin epoxy 2-Chloro-2-methylpropane Calcium chloride Propofol 1,1,1,2,3,3,3-HEPTACHLOROPROPANE Isopropyl acetate 1-Chloropropane Diphenyldichloromethane 2-​[[(2-​ethylphenyl)​(2-​hydroxyethyl)​amino]​methyl]​-​3,​3-​difluoro-Propanenitrile (-)-ISOPROTERENOL HYDROCHLORIDE PROMETHAZINE 2-Chloropropane

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