Scopine-2,2-dithienyl glycolate

Scopine-2,2-dithienyl glycolate Basic information
Description
Product Name:Scopine-2,2-dithienyl glycolate
Synonyms:SCOPINE-2,2-DITHIENYL GLYCOLATE;(1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl 2-hydroxy-2,2-dithiophen-2-ylacetate;Tiotropium EP Impurity B;2-Thiopheneacetic acid, -hydroxy--2-thienyl-, (1,2,4,5,7);2-thiopheneacetic acid, a-hydroxy-a-2th ( Di(2-thienyl) Glycolate );N-DeMethyl TiotropiuM;α-Hydroxy-α-2-thienyl-2-thiopheneacetic Acid (1α,2β,4β,5α,7β)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester;Scopine di(2-thienyl)glycolate scopine-2-dithienyl glycolate
CAS:136310-64-0
MF:C18H19NO4S2
MW:377.48
EINECS:603-953-6
Product Categories:Heterocycles;Intermediates & Fine Chemicals;TIOTROPIUM BROMIDE;Pharmaceuticals;Tiotropium Bromide Intermediates;136310-64-0
Mol File:136310-64-0.mol
Scopine-2,2-dithienyl glycolate Structure
Scopine-2,2-dithienyl glycolate Chemical Properties
Melting point 138-140°C
Boiling point 542.3±50.0 °C(Predicted)
density 1.48±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility Chloroform (Slightly), Methanol (Slightly, Heated)
pka10.32±0.29(Predicted)
form Solid
color White to Off-White
Safety Information
MSDS Information
Scopine-2,2-dithienyl glycolate Usage And Synthesis
Description

Scopine-2,2-dithienyl glycolate is an organic compound. It is off-white solid. The melting point is 138-140°C. The storage temperature is -20°C. Scopine-2,2-dithienyl glycolate is one of the reaction intermediates in the preparation of tiotropium bromide, which is a highly effective anticholinergic agent and widely used for treatment of asthma and/or chronic obstructive pulmonary disease (COPD) (chronic obstructive pulmonary disease).

Chemical PropertiesOff-White Solid
UsesScopine Di(2-thienylglycolate) (Tiotropium EP Impurity B) is a precursor to Tiotropium Bromide.
Scopine-2,2-dithienyl glycolate Preparation Products And Raw materials
Preparation ProductsTiotropium bromide hydrate
Methyl 2,2-dithienylglycolate (2S,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid PWKRNMKZGWGSDV-UHFFFAOYSA-N Base alcohol Methyl glycolate [R(R*,R*]-2-amino-1-[p-(methylsulphonyl)phenyl]propane-1,3-diol 4-Benzyl Albuterol Thioglycollate Broth (USP Alternative) 2-Diethylaminoethyl hexanoate 2-HYDROXY-2,2-BIS(2-THIENYL) ACETIC ACID Starch, hydrogen phosphate, 2-hydroxypropyl ether Tiotropium bromide 2-Thiopheneethanol Tetrahydrothiophene Scopine Tiotropium bromide hydrate Glycolic acid Scopine-2,2-dithienyl glycolate

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