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| | 1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE Basic information |
| Product Name: | 1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE | | Synonyms: | 1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE;DR 2313;7,8-Dihydro-2-methyl-1H-thiopyrano[4,3-d]pyrimidin-4(5H)-one;3,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one;4H-Thiopyrano[4,3-d]pyriMidin-4-one,3,5,7,8-tetrahydro-2;4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE,3,5,7,8-TETRAHYDRO-2-METHYL-;SC-202756;2-Methyl-1-sulfanyl-1H,4H,5H,7H,8H-pyrano[4,3-d]pyriMidin-4-one | | CAS: | 284028-90-6 | | MF: | C8H10N2OS | | MW: | 182.24 | | EINECS: | 200-589-5 | | Product Categories: | | | Mol File: | 284028-90-6.mol | ![1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE Structure](CAS/GIF/284028-90-6.gif) |
| | 1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE Chemical Properties |
| Boiling point | 349.3±52.0 °C(Predicted) | | density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | H2O: >2mg/mL (warmed) | | form | powder | | pka | 1.54±0.20(Predicted) | | color | white to beige |
| | 1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE Usage And Synthesis |
| Biological Activity | Potent, competitive inhibitor of poly(ADP-ribose) polymerase (PARP) (IC 50 values are 0.20 and 0.24 μ M for PARP-1 and PARP-2 respectively). Neuroprotective; reduces neuronal cell death in models of cerebral ischemia in vivo and in vitro . Brain penetrant. |
| | 1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE Preparation Products And Raw materials |
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