ChemicalBook Product Catalog Biochemical Engineering Inhibitors Neuronal Signaling Opioid Receptor Antagonists JTC 801

JTC 801

JTC 801 Basic information
Product Name:JTC 801
Synonyms:JTC 801;N-(4-Amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]benzamidehydrochloride;N-(4-Amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]benzamide monohydrochloride;JTC 801 HCl;JTC-801 hydrochloride;JTC-801/JTC801;N-(4-AMino-2-Methyl-quinolin-6-yl)-2-(4-ethyl-phenoxyMethyl)-benzaMide hydrochloride;Benzamide,N-(4-amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]-, hydrochloride
CAS:244218-51-7
MF:C26H25N3O2.ClH
MW:447.963
EINECS:
Product Categories:Inhibitors
Mol File:244218-51-7.mol
JTC 801 Structure
JTC 801 Chemical Properties
Melting point 235℃
storage temp. Inert atmosphere,2-8°C
solubility DMSO: ≥20mg/mL
form powder
color tan
InChIKeyNQLIYKXNAXKMBL-UHFFFAOYSA-N
Safety Information
Hazard Codes Xi
Risk Statements 36
Safety Statements 26
WGK Germany 1
MSDS Information
JTC 801 Usage And Synthesis
UsesJTC 801 is a novel opioid receptor-like1 (ORL1) receptor antagonist.
Biological ActivityHigh affinity, selective NOP receptor antagonist (K i = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human μ -, κ - and δ -opioid receptors respectively. In vivo shows anti-nociceptive effects in acute pain models. Orally active.
storageDesiccate at RT
JTC 801 Preparation Products And Raw materials
Ozagrel 2-Methylaminoethanol N-Methyldiethanolamine PD 0325901 NSC319726 SB 415286 N-Methylbenzylamine 4,6-DIAMINO-2-METHYL-QUINOLINE 2-(PHENOXYMETHYL)BENZYLAMINE 97 N-METHYL-2-(PHENOXYMETHYL)BENZYLAMINE JTC 801
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