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| | Ethoxymethylenemalononitrile Basic information |
| | Ethoxymethylenemalononitrile Chemical Properties |
| | Ethoxymethylenemalononitrile Usage And Synthesis |
| Description | Ethoxymethylenemalononitrile (EMMN) is an orange solid and the melting point of EMMN is 64–66 °C[1].It is an inexpensive reagent. As a functionalized malono-nitrile, it is widely used to synthesize pyrazoles, pyrimidines and a variety of fused heterocyclic systems. | | Chemical Properties | Off White to Pale Yellow | | Uses | Ethoxymethylene Malononitrile (cas# 123-06-8) is a compound useful in organic synthesis. | | Uses | Chemical intermediate. | | Preparation | Triethyl orthoformate (67.3 mg, 0.454 mol) and malononitrile (20.0 mg,0.302 mol) were andded to acetic anhydride (77.2 gm, 0.75 moles) and the mixture was refluxed for 4-5 h at 110-140°C. The reaction was monitored by GC. After the reaction is complete, it is cooled to room temperature. Concentrated the mixture at 70°C at reduced pressure to yield crude solid product and the pure product (Ethoxymethylenemalononitrile) was obtained through purified either by vacuum distillation.
 | | Synthesis Reference(s) | Tetrahedron Letters, 10, p. 3279, 1969 DOI: 10.1017/S0009838800024678 | | References | [1] Faria J, et al. Ethoxymethylenemalononitrile. Synlett , 2013; 24: 0264–0265.
[2] Maurício , et al. Synthesis and antileishmanial evaluation of 1-aryl-4-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazole derivatives. Bioorganic & Medicinal Chemistry Letters, 2011; 21: 7451-7454. |
| | Ethoxymethylenemalononitrile Preparation Products And Raw materials |
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