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| | Monensin Basic information |
| Product Name: | Monensin | | Synonyms: | 2-(5-ethyltetrahydro-5-(tetrahydro-3-6-dioxaspiro(4.5)decane-7-butyricacid;a3823a;elancoban;gamma,2,8-tetramethyl--furyl)-2-furyl)-9-hydroxy-beta-methoxy-alph;monelan;Monensine sodium;4-[2-[2-Ethyl-5-(6-hydroxy-6-hydroxymethyl-3,5-dimethyltetrahydropyran-2-yl)-3-methyloctahydro-[2,2]bifuranyl-5-yl]-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]-3-methoxy-2-methylpentanoic acid;Monensin A | | CAS: | 17090-79-8 | | MF: | C36H62O11 | | MW: | 670.87 | | EINECS: | 241-154-0 | | Product Categories: | Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;API's | | Mol File: | 17090-79-8.mol |  |
| | Monensin Chemical Properties |
| Melting point | 103-105°C | | alpha | D +47.7° | | Boiling point | 608.24°C (rough estimate) | | density | 1.0773 (rough estimate) | | refractive index | 1.5465 (estimate) | | storage temp. | 2-8°C | | pka | 6.6 (in 66% DMF) | | CAS DataBase Reference | 17090-79-8(CAS DataBase Reference) | | EPA Substance Registry System | Monensin (17090-79-8) |
| | Monensin Usage And Synthesis |
| Chemical Properties | Crystallin Solid | | Uses | Monensin A is a polyether antibiotic first isolated from Streptomyces cinnamonensis in 1967. Monensin A is a broad-spectrum anticoccicidial antibiotic, also exhibiting antifungal and antiviral activity. Monensin A forms complexes with monovalent cations such as Li+, Na+, K+, Rb+, Ag+ and Tl+ and is thus able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport and is used in animals to prevent coccidiosis, promote growth and prevent bloat. Derivatives of monensin, monensin methyl ester and particularly monensin decyl ester, are used in ion selective electrodes. | | Uses | Monensin (2) C36H62O11, a carboxylic acid which is used as its water-soluble sodium salt (Coban, Rumensin). Monensin is also used to treat histomoniasis. The polyether ionophoric antibiotics are capable of complexing and interfacing with specific alkali metal cations to render them lipid-soluble and diffusible across parasite mitochondrial membranes. Related useful polyether antibiotics are narasin and lasalocid (3, Lasalocid A, C34H54O8,). | | Uses | Poliether antibiotic. Coccidiostat | | Definition | ChEBI: Monensin A is a spiroketal, monensin A is the major component of monensin, a mixture of antibiotic substances produced by Streptomyces cinnamonensis. An antiprotozoal, it is used as the sodium salt as a feed additive for the prevention of coccidiosis in poultry and as a growth promoter in cattle. It has a role as a coccidiostat, an antifungal agent and an ionophore. It is a monocarboxylic acid, a cyclic hemiketal, a spiroketal and a polyether antibiotic. | | Brand name | Coban [as sodium salt] (Lilly);Rumensin [as sodium salt] (Lilly). | | Safety Profile | Poison by ingestion and
intraperitoneal routes. An eye and skin
irritant. When heated to decomposition it
emits acrid smoke and irritating fumes. |
| | Monensin Preparation Products And Raw materials |
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