ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Pyridine derivatives 2-Benzoylpyridine

2-Benzoylpyridine

2-Benzoylpyridine Basic information
Product Name:2-Benzoylpyridine
Synonyms:ketone,phenyl2-pyridyl;Phenyl(2-pyridinyl)methanone;phenyl-2-pyridinyl-methanon;Pyridine, 2-benzoyl-;AKOS B022444;AKOS 94378;2-BENZOYLPYRIDINE;PHENYL(PYRIDIN-2-YL)METHANONE
CAS:91-02-1
MF:C12H9NO
MW:183.21
EINECS:202-034-3
Product Categories:Pyridines derivates
Mol File:91-02-1.mol
2-Benzoylpyridine Structure
2-Benzoylpyridine Chemical Properties
Melting point 41-43 °C (lit.)
Boiling point 317 °C (lit.)
density 1,556 g/cm3
refractive index 1.5880 (estimate)
Fp 302 °F
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
pka2.90±0.10(Predicted)
form Crystalline Chunks
color Colorless to slightly yellow
Water Solubility insoluble
BRN 120283
LogP1.880
CAS DataBase Reference91-02-1(CAS DataBase Reference)
NIST Chemistry ReferenceMethanone, phenyl-2-pyridinyl-(91-02-1)
EPA Substance Registry SystemMethanone, phenyl-2-pyridinyl- (91-02-1)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS OB6400000
Hazard Note Irritant
TSCA Yes
HS Code 29333999
MSDS Information
ProviderLanguage
Phenyl-2-pyridyl ketone English
SigmaAldrich English
ACROS English
ALFA English
2-Benzoylpyridine Usage And Synthesis
Chemical PropertiesCOLOURLESS TO SLIGHTLY YELLOW CRYSTALLINE CHUNKS
UsesOrganic synthesis.
Uses2-Benzoylpyridine is used as a reagent to assist crosslinking in acrylic coating compounds in the polymers industry. 2-Benzoylpyridine is also a precursor for thioemicarbazone compounds that exhibit high cytotoxic activity against human leukemia cell lines and also posesses some antiinflammatory qualities.
Synthesis Reference(s)Journal of Heterocyclic Chemistry, 24, p. 1061, 1987 DOI: 10.1002/jhet.5570240429
Tetrahedron Letters, 25, p. 1715, 1984 DOI: 10.1016/S0040-4039(01)81152-7
Purification MethodsDissolve 2-benzoylpyridine in Et2O, shake it with aqueous NaHCO3, H2O, dry it over MgSO4 and evaporate. The residue solidifies on cooling. The solid can be recrystallised from pet ether. Its hydrochloride crystallises from Me2CO, m 126-127o, and the 2,4-dinitrophenylhydrazone has m 193-195o. It distils at high vacuum. [Kinkerton & Thames J Organomet Chem 24 623 1970, Beilstein 21/8 V 566.]
RARECHEM AQ NN 0216 (4-CHLOROPHENYL)[3-(1-PYRROLIDINYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]METHANONE [3-MORPHOLINO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](PHENYL)METHANONE (4-CHLOROPHENYL)[3-(4-PHENYLPIPERAZINO)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]METHANONE [3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](3-METHOXYPHENYL)METHANONE [3-(DIMETHYLAMINO)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](PHENYL)METHANONE [3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL][3-(TRIFLUOROMETHYL)PHENYL]METHANONE [3-(4-METHYLPIPERAZINO)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](4-NITROPHENYL)METHANONE Difenoconazole PHENYL VALERATE (2,4-DICHLOROPHENYL)[3-PHENOXY-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]METHANONE 2,6-Lutidine 2-Hydroxypyridine 1-ISOQUINOLINYL PHENYL KETONE Benzoyl chloride (4-CHLOROPHENYL)[3-(4-HYDROXYPHENOXY)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]METHANONE [3-(DIMETHYLAMINO)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](4-NITROPHENYL)METHANONE 2-Benzoylpyridine
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