ChemicalBook Product Catalog Pharmaceutical intermediates (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Basic information
Product Name:(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms:(3R)-3-(Hydroxymethyl)piperazine, N1-BOC protected 98%;tert-Butyl (3R)-3-(hydroxymethyl)-1-piperazinecarboxylate;(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-4-N-BOC-2-HYDROXYMETHYL-PIPERAZINE;(R)-1-Boc-3-hydroxymethyl-piperazine;(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate;H57159;(R)-4-Boc-2-hydroxymethyl-piperazine
CAS:278788-66-2
MF:C10H20N2O3
MW:216.28
EINECS:
Product Categories:pharmacetical;Piperaizine
Mol File:278788-66-2.mol
(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Structure
(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties
Melting point 68-70°C
Boiling point 322.9±22.0 °C(Predicted)
density 1.085±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka14.97±0.10(Predicted)
color White to Off-White
InChIInChI=1S/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-8(6-12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m1/s1
InChIKeyNSILYQWHARROMG-MRVPVSSYSA-N
SMILESN1(C(OC(C)(C)C)=O)CCN[C@@H](CO)C1
CAS DataBase Reference278788-66-2(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 41-52
Safety Statements 26-39
HS Code 2933599590
MSDS Information
(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Usage And Synthesis
Uses(R)-1-Boc-3-hydroxymethylpiperazine is a used as a building block for the preparation of PI3K inhibitors for rheumatoid arthritis treatment,benzoxaborole derivatives as antimalarial agents and anti-tuberculosis agents.
(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials3H-Oxazolo[3,4-a]pyrazine-7(1H)-carboxylic acid, tetrahydro-1,3-dioxo-, 1,1-dimethylethyl ester, (8aR)--->(R)-1,4-(DI-BOC)-2-(HYDROXYMETHYL)PIPERAZINE
(R)-N-Boc-piperazine-2-carboxylic acid methyl ester (S)-4-N-Boc-2-(hydroxymethyl)piperazine (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester N-4-Boc-2-piperazinecarboxylic acid (R)-1-(((9H-FLUOREN-9-YL)METHOXY)CARBONYL)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID R-N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid 2-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE (R)-2-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester (S)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-N-Boc-2-(hydroxymethyl)piperazine (S)-1-Boc-2-Hydroxymethyl-piperazine (R)-1-N-Boc-2-(hydroxymethyl)piperazine (R)-1-N-BOC-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID (S)-2-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
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