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| | Z-PHE-DL-ALA-FLUOROMETHYLKETONE Basic information |
| Product Name: | Z-PHE-DL-ALA-FLUOROMETHYLKETONE | | Synonyms: | Z-PHE-DL-ALA-FLUOROMETHYLKETONE;Carbamic acid,N-[(1S)-2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-,phenylmethyl ester;Nalpha-[(Benzyloxy)Carbonyl]-N-(4-Fluoro-3-Oxo-2-Butanyl)Phenylalaninamide z-fa-fmk;Nalpha-[(Benzyloxy)Carbonyl]-N-(4-Fluoro-3-Oxo-2-Butanyl)Phenylalaninamide;CS-1504;Z-Phe-DL-Ala-FMK;Benzyl ((2S)-1-((4-fluoro-3-oxobutan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate;SARS coronavirus,SARS-CoV,RRMs,DNA fragmentation,DEVDase,Caspase,Cathepsin,Inhibitor,externalization of phosphatidylserine,Apoptosis,inhibit,Z FA FMK,reovirus replication,ZFAFMK | | CAS: | 197855-65-5 | | MF: | C21H23FN2O4 | | MW: | 386.42 | | EINECS: | | | Product Categories: | Inhibitors;API | | Mol File: | 197855-65-5.mol |  |
| | Z-PHE-DL-ALA-FLUOROMETHYLKETONE Chemical Properties |
| Boiling point | 630.5±55.0 °C(Predicted) | | density | 1?+-.0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,2-8°C | | solubility | DMF: 5 mg/ml; DMSO: 5 mg/ml | | form | White solid | | pka | 11.07±0.46(Predicted) |
| | Z-PHE-DL-ALA-FLUOROMETHYLKETONE Usage And Synthesis |
| Description | Z-FA-FMK is an irreversible inhibitor of cysteine proteases, including cathepsins B, L, and S, cruzain, and papain. It also inhibits effector caspases-2, -3, -6, and -7 (IC50 = 6-32 μM) without affecting the initiator caspases-8 and -10. Z-FA-FMK also modulates infection by certain bacteria, parasites, and viruses. It can be used both in cells and in vivo. | | Uses | Z-FA-FMK is an irreversible cysteine protease inhibitor. It also inhibits papain and cruzain. |
| | Z-PHE-DL-ALA-FLUOROMETHYLKETONE Preparation Products And Raw materials |
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