ChemicalBook Product Catalog Organic Chemistry Heterocyclic Compounds 3-Quinuclidinol

3-Quinuclidinol

3-Quinuclidinol Basic information
Product Name:3-Quinuclidinol
Synonyms:3-Hydroxyxinyclidine;dl-3-Quinuclidinol;NSC 93905;1-Azabicyclo[2.2.2]octan-3-ol, 3-Hydroxyquinuclidine;QUINICLIDINE-3-OL;3-Quinuclidinol,99%;2-Amino-N-ethylbenze;Quinuclidin-3-ol, 1-Azabicyclo[2.2.2]octan-3-ol
CAS:1619-34-7
MF:C7H13NO
MW:127.18
EINECS:216-578-4
Product Categories:Heterocycles;Intermediates & Fine Chemicals;Pharmaceutical material and intermeidates;Quinuclidine derivatives;Pharmaceuticals
Mol File:1619-34-7.mol
3-Quinuclidinol Structure
3-Quinuclidinol Chemical Properties
Melting point 220-223 °C(lit.)
Boiling point 235.98°C (rough estimate)
density 1.0083 (rough estimate)
refractive index 1.4790 (estimate)
storage temp. 2-8°C
solubility Aqueous Acidic (Slightly), Chloroform (Sparingly), Methanol (Slightly)
pka14.75±0.20(Predicted)
form Crystalline Powder
color White to beige
Water Solubility soluble
Sensitive Air Sensitive
Merck 14,8082
BRN 104327
LogP0.17
CAS DataBase Reference1619-34-7(CAS DataBase Reference)
NIST Chemistry Reference3-Quinuclidinol(1619-34-7)
EPA Substance Registry System1-Azabicyclo[2.2.2]octan-3-ol (1619-34-7)
Safety Information
Hazard Codes C,F
Risk Statements 34-11
Safety Statements 26-36/37/39-45-16
RIDADR UN 3263 8/PG 2
WGK Germany 3
RTECS VD6191700
F 34
Hazard Note Corrosive
TSCA Yes
HazardClass 8
PackingGroup III
HS Code 29333920
Hazardous Substances Data1619-34-7(Hazardous Substances Data)
MSDS Information
ProviderLanguage
3-Quinuclidinol English
SigmaAldrich English
ALFA English
3-Quinuclidinol Usage And Synthesis
Chemical PropertiesCrystalline Solid
UsesHypotensive. Synthon for preparation of cholinergic receptor ligands and anesthetics
Uses3-Quinuclidinol acts as a chiral building block for various antimuscarinic agents and other active pharmaceutical ingredients. It serves as a catalyst for condensation of methyl vinyl ketone with aldehydes. It is also used as a reagent for cleavage of beta-keto and vinylogous beta-keto esters. Further, it plays an important role as a synthon in the preparation of cholinergic receptor ligands and anesthetics. In addition to this, it is used in chemoselective alfa-iodination of acrylic esters through Morita-Baylis-Hillman reaction.
DefinitionChEBI: Quinuclidine in which a hydrogen atom at position 3 is substituted by a hydroxy group.
HazardMutation.
3-Quinuclidinol Preparation Products And Raw materials
(R )-(-)-3-hydroxyquinuclidine (R)-()-3-Quinuclidinol,(R)-3-QUINUCLIDINOL,(R)-(-)-3-Quinuclidinol, 99+%,(R)-(-)-3-QUINUCLIDINOL (S)-3-Quinuclidinol. Hydrochloride,(S)-(+)-3-QUINUCLIDINOL 2-METHYLENE-3-QUINUCLIDINONE HYDROCHLORIDE HYDRATE Carbamic acid, (2-(heptyloxy)phenyl)-, 1-azabicyclo(2.2.2)oct-3-yl est er, monohydrochloride 3-Quinuclidinol benzilate,3-Quinuclidinol, benzilate (ester),3-Quinuclidinol hydroxydiphenylacetate N-METHYL L-QNB, [N-METHYL-3H]- L-QUINUCLIDINYL BENZILATE, [BENZYLIC-4,4'-3H(N)] Quinine sulfate dihydrate Clidinium bromide Aceclidine Hydrochloride Cyproconazol 3-Quinuclidinol acetate ester QUINUCLIDINE Espatropate (R)-(-)-3-QUINUCLIDINYL BENZILATE 3-QUINUCLIDINOL HCL,3-QUINUCLIDINOL HYDROCHLORIDE 3-Quinuclidinol 2-[(4-METHOXYPHENYL)METHYLENE]-3-QUINUCLIDINOL Quinuclidinol
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