2-Hydrazinopyrazine

2-Hydrazinopyrazine Basic information
Product Name:2-Hydrazinopyrazine
Synonyms:PYRAZIN-2-YL-HYDRAZINE;2-Hydrazinylpyrazine;Pyrazin-2-yl-hydrazine ,97%;1-(pyrazin-2-yl) hydrazine;2-Hydrazinopyrazine ,97%;1-(pyrazin-2-ylydrazine;2-HYDRAZINOPYRAZINE;2-Hydrazinylpyrazine HCl
CAS:54608-52-5
MF:C4H6N4
MW:110.12
EINECS:
Product Categories:
Mol File:54608-52-5.mol
2-Hydrazinopyrazine Structure
2-Hydrazinopyrazine Chemical Properties
Melting point 109-113℃
Boiling point 246.3±23.0 °C(Predicted)
density 1.39±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka5.10±0.20(Predicted)
form Solid
color Yellow
Water Solubility Slightly soluble in water.
Safety Information
Hazard Codes Xn
Risk Statements 22-41-36/37/38
Safety Statements 26-39-36/37/39
HS Code 29339900
MSDS Information
2-Hydrazinopyrazine Usage And Synthesis
Chemical PropertiesPale yellow solid
UsesTriazolo[4,3-a]pyrazine 7-oxide, 3-β-D-ribofuranosyl-1,2,4-triazolo[4,3-a]pyrazine, monohydrazones of pyridine, pyrazine, phenylglyoxal were synthesised from 2-Hydrazinopyrazine.
Application2-Hydrazinopyrazine is used as a reagent in the synthesis of Sitagliptin (S491000, H3PO4) and its analogs. Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor that has recently been approved for the therapy of type II diabetes.
2-Hydrazinopyrazine Preparation Products And Raw materials
Preparation Products3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazole-->KPT-330-->3-Methyl-1,2,4-triazolo[4,3-a]pyrazine
4-CHLOROBENZENECARBALDEHYDE N-[3-(TRIFLUOROMETHYL)-2-QUINOXALINYL]HYDRAZONE 2,6-DICHLORO-3-HYDRAZINOQUINOXALINE 2-HYDRAZINO-3-(TRIFLUOROMETHYL)QUINOXALINE N-(4-CHLOROPHENYL)-2-[3-(TRIFLUOROMETHYL)-2-QUINOXALINYL]-1-HYDRAZINECARBOXAMIDE 3-HYDRAZINO-QUINOXALINE-2-THIOL BENZENECARBALDEHYDE N-[3-(TRIFLUOROMETHYL)-2-QUINOXALINYL]HYDRAZONE AURORA 13895 2-HYDRAZINOQUINOXALINE 5,6-DIHYDRAZINO[1,2,5]OXADIAZOLO[3,4-B]PYRAZINE N-(4-CHLOROPHENYL)-2-METHYL-2-[3-(TRIFLUOROMETHYL)-2-QUINOXALINYL]-1-HYDRAZINECARBOXAMIDE 2-CHLORO-5-HYDRAZINO-3,6-DIPHENYLPYRAZINE 2-(1-METHYLHYDRAZINO)QUINOXALINE AURORA 13994 AKOS BBS-00004524 2,4-DICHLOROBENZENECARBALDEHYDE N-[3-(TRIFLUOROMETHYL)-2-QUINOXALINYL]HYDRAZONE NICOTINALDEHYDE N-[3-(TRIFLUOROMETHYL)-2-QUINOXALINYL]HYDRAZONE N-(4-CHLOROPHENYL)-2-(3-CHLORO-2-QUINOXALINYL)-1-HYDRAZINECARBOXAMIDE 2-(1-METHYLHYDRAZINO)-3-(TRIFLUOROMETHYL)QUINOXALINE

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