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| | 6-IODONORDIHYDROCAPSAICIN Basic information |
| | 6-IODONORDIHYDROCAPSAICIN Chemical Properties |
| Melting point | 106-107 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) | | Boiling point | 552.9±50.0 °C(Predicted) | | density | 1.375±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | H2O: insoluble | | pka | 8.93±0.25(Predicted) | | form | solid | | color | white |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | 6-IODONORDIHYDROCAPSAICIN Usage And Synthesis |
| Uses | 6-?iodonordihydrocapsaicin (6-?I-?CPS) is a weak ERα agonist. It was demonstrated to induce luciferase gene expression. | | Definition | ChEBI: N-[(4-hydroxy-2-iodo-5-methoxyphenyl)methyl]nonanamide is a member of phenols and a member of methoxybenzenes. | | Biological Activity | the vanilloid trpv1 receptor, also known as vr1 receptor, belongs to the large family of ‘transient receptor potential’ (trp). trpv1 functions as a molecular integrator of nociceptive stimuli, including heat, protons and plant toxins, and is most abundant in peripheral sensory fibers of the c and ad type. 6-iodo-nordihydrocapsaicin is a potent trpv1 antagonist. | | in vitro | using human recombinant trpv1, 6-iodonordihydrocapsaicin (ic50=10 nm against 100 nm capsaicin) was about four times more potent than the prototypical trpv1 antagonist, capsazepine [1]. | | in vivo | 6-iodonordihydrocapsaicin was tested against capsaicin also on native trpv1 in: (i) rat dorsal root ganglion neurons in culture; (ii) guinea-pig urinary bladder; and (iii) guinea-pig bronchi. in all cases, except for the guineapig bronchi, the compound was significantly more potent than capsazepine as a trpv1 antagonist [1]. | | IC 50 | 10 nm against 100 nm capsaicin | | references | [1] appendino g, harrison s, de petrocellis l, daddario n, bianchi f, schiano moriello a, trevisani m, benvenuti f, geppetti p, di marzo v. halogenation of a capsaicin analogue leads to novel vanilloid trpv1 receptor antagonists. br j pharmacol. 2003 aug;139(8):1417-24. |
| | 6-IODONORDIHYDROCAPSAICIN Preparation Products And Raw materials |
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