ChemicalBook Product Catalog API Antineoplastic agents Alkylating antineoplastic Fotemustine

Fotemustine

Fotemustine Basic information
Product Name:Fotemustine
Synonyms:1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea;FOTEMUSTINE;Fotemustin;Muphoran;S-10036;Phosphonic acid, P-[1-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]ethyl]-, diethyl ester;[1-[[[(2-Chloroethyl)nitlx~amino]carbonyl]amino]ethyl]phosphonic acid diethyl ester;[1-[[[(2-Chloroethyl)nitrosoamino]carbonyl]amino]ethyl]phosphonic acid diethyl ester
CAS:92118-27-9
MF:C9H19ClN3O5P
MW:315.69
EINECS:
Product Categories:
Mol File:92118-27-9.mol
Fotemustine Structure
Fotemustine Chemical Properties
Melting point 85°
density 1.37±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility H2O: ≥1mg/mL
form powder
pka9.47±0.46(Predicted)
color light yellow
CAS DataBase Reference92118-27-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 40
Safety Statements 36/37
WGK Germany 3
Hazardous Substances Data92118-27-9(Hazardous Substances Data)
MSDS Information
Fotemustine Usage And Synthesis
DescriptionFotemustine is a new nitrosourea reportedly effective in the treatment of disseminated malignant melanoma, with only mild hematological toxicity. Response rate is generally lower in patients with colonic, breast, head and neck cancer.
OriginatorServier (France)
UsesFotemustine is used in patients malignant gliomas to improve the efficacy of radiotherapy. Used in the treatment of glioblastomas.
DefinitionChEBI: Diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonate is a member of the class of N-nitrosoureas that is ethyl diethylphosphonate in the hydrogen at position 1 of the ethyl group attached to the phosphorus has been replaced by a [(2-chloroethyl)(nitroso)carbamoyl]amino group. It is an organic phosphonate, a member of N-nitrosoureas and an organochlorine compound.
Brand nameMuphoran
Fotemustine Preparation Products And Raw materials
Raw materials2-Chloroethyl isocyanate
N-NITROSOMETHYL-2-CHLOROETHYLAMINE Bendamustine hydrochloride Triethyl phosphate Bendamustine Ethyl dichlorophosphate N,N'-dimethylnitrosourea 1-Methyl-1-nitrosourea 1-(2-chloroethyl)-1-nitrosourea 1-nitroso-1-ethyl-3-methylurea DIETHYL N-FORMYL-AMINOMETHYL PHOSPHONATE Diethyl phosphite DIETHYL PHOSPHATE (AMINOMETHYL)PHOSPHONIC ACID HYDROCHLORIDE N-NITROSO-N-ETHYLUREA ETHYLPHOSPHONIC ACID N-Nitrocarbamide Fotemustine Triethyl phosphite
Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.