COLCHICOSIDE

COLCHICOSIDE Basic information
Product Name:COLCHICOSIDE
Synonyms:Colchicine Impurity 4(Colchicine EP Impurity D);Colchicine EP impurity D (Colchicoside);Colchicine impurity D;(S)-7-Acetylamino-6,7-dihydro-3-(β-D-glucopyranosyloxy)-1,2,10-trimethoxybenzo[a]heptalen-9(5H)-one;Aids012001;Aids-012001;N-[3-(Hexopyranosyloxy)-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[A]heptalen-7-yl]acetamide;Nsc32992
CAS:477-29-2
MF:C27H33NO11
MW:547.554
EINECS:207-513-0
Product Categories:Miscellaneous Natural Products;Carbohydrates & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:477-29-2.mol
COLCHICOSIDE Structure
COLCHICOSIDE Chemical Properties
Melting point 194-197°C
Boiling point 620.17°C (rough estimate)
density 1.3430 (rough estimate)
refractive index 1.6400 (estimate)
storage temp. Refrigerator
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
form A crystalline solid
pka12.74±0.70(Predicted)
Safety Information
MSDS Information
COLCHICOSIDE Usage And Synthesis
Chemical PropertiesPale Yellow Solid
UsesA significantly toxic Colchicine analog with no anti-inflammatory properties.
DefinitionChEBI: Colchicoside is a carbotricyclic compound, an alkaloid and a member of acetamides.
Purification MethodsPurify colchicoside by chromatography through alumina and eluting with CHCl3, then recrystallising from Me2CO, m 275-280o (after releasing solvent at 180o). It also crystallises from EtOH; see colchicine. The tetraacetate has m 175-177o, [] D 15 -57o (c 1, CHCl3). [Bellet et al. Ann Pharm Fr 10 241 1952, Chem Abstr 47 3323 1953, Beilstein 14 IV 946 for colchicine.]
COLCHICOSIDE Preparation Products And Raw materials
Colchicine Hexyliso-eugenol trimethylcolchicinic acid methyl ether TRIMETHYLCOLCHICINIC ACID colchicide DEMECOLCINE colchiceine 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone 2-Demethyl Colchicine GLORIOSINE Tropolone desacetamidocolchicine COLCHICOSIDE

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