Amiloride hydrochloride dihydrate Chemical Properties
Melting point
>240℃
RTECS
UQ2275500
storage temp.
Store at -20°C
solubility
Slightly soluble in water and in anhydrous ethanol.
pka
8.7(at 25℃)
form
neat
Water Solubility
Soluble in water at 50mg/ml
Safety Information
WGK Germany
3
HazardClass
6.1
HS Code
2933995300
MSDS Information
Amiloride hydrochloride dihydrate Usage And Synthesis
Chemical Properties
Pale yellow or greenish-yellow powder.
Uses
Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 ?M. Amiloride ? HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.
Uses
Diuretic;Antialdosteron
Uses
An epithelial sodium channel blocker
Definition
ChEBI: A hydrate that is the dihydrate of amiloride hydrochloride.
Brand name
Midamor (Merck).
Amiloride hydrochloride dihydrate Preparation Products And Raw materials
