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| | Bepridil hydrochloride Basic information |
| Product Name: | Bepridil hydrochloride | | Synonyms: | Bepridil hydrochloride hydrate;3-isobutoxy-2-pyrrolidino-n-phenyl-n-benzylpropylaminehydrochloridehydrate;angopril;l)-,monohydrochloride,monohydrate;Bepridil hydrochloride;1-Isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane hydrochloride;1-Pyrrolideneethanamine, beta-((2-methylpropoxy)methyl)-N-phenyl-N-(phenylmethyl)-, monohydrochloride, monohydrate;Unii-4W2p15D93m | | CAS: | 74764-40-2 | | MF: | C24H37ClN2O2 | | MW: | 421.01578 | | EINECS: | | | Product Categories: | GLIADEL;API | | Mol File: | 74764-40-2.mol |  |
| | Bepridil hydrochloride Chemical Properties |
| Melting point | 91 ±2° | | storage temp. | Desiccate at RT | | solubility | Soluble in DMSO (up to 25 mg/ml) or ethanol (up to 25 mg/ml) | | form | powder | | color | white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| WGK Germany | 2 | | RTECS | UY1162000 | | Toxicity | LD50 in mice (mg/kg): 1955 orally, 23.5 i.v. (Mauvernay, 1978) |
| | Bepridil hydrochloride Usage And Synthesis |
| Description | Bepridil (74764-40-2) is a clinically useful calcium channel blocker with antianginal activity.1 It has recently been shown to possess potent activity against SARS-CoV-2 in vitro.2 Bepridil was also able to provide protection from Ebola virus3 and other filoviruses in a mouse model4. | | Uses | antineoplastic, alkylating agent | | Uses | Bepridil Hydrochloride is a calcium channel blocker. It also activates mitochondrial ATP-sensitive KATP channelsBepridil Hydrochloride is an antiarrhythmic and antihypertensive agent and used for treating atrial fibrillation. | | Definition | ChEBI: The hydrochloride monohydrate of bepridril. | | Brand name | Bepadin
(Medpointe); Vascor (Johnson & Johnson). | | General Description | Bepridil hydrochloride,β-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethylamine hydrochloride (Vascor), is a secondgenerationalkylamine-type channel blocker, structurallyunrelated to the dihydropyridines. Its actions are less specificthan those of the three prototypical channel blockers,verapamil, diltiazem, and nifedipine. In addition to being aCa2+ channel blocker, it inhibits sodium flow into the hearttissue and lengthens cardiac repolarization, causing bradycardia.Caution should be used if it is given to a patient withhypokalemia. Bepridil hydrochloride is used for stableangina. The drug has a half-life of 33 hours and is highlybound to protein (99%). | | Hazard | Moderately toxic by ingestion. | | Biochem/physiol Actions | Non-selective calcium channel blocker and class IV antiarrhythmic agent; inhibits Na+-Ca2+ exchange; inhibits growth of brain tumor cells in vitro. | | References | Hollingshead et al. (1992), A review of its pharmacological properties and therapeutic use in stable angina pectoris; Drugs, 44 835
Vatansever et al. (2021), Bepridil is potent against SARS-CoV-2 in vitro; Proc. Natl. Acad. Sci USA, 118 e2012201118
Johansen et al. (2015), A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity; Sci. Transl. Med., 7 290ra89
DeWald et al. (2018), The calcium channel blocker bepridil demonstrates efficacy in the murine model of marburg virus disease; J. Infect. Dis., 218(suppl 5) S588 |
| | Bepridil hydrochloride Preparation Products And Raw materials |
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