2-Chlorobenzaldehyde

2-Chlorobenzaldehyde Basic information

Product Name:	2-Chlorobenzaldehyde
Synonyms:	2-chlorobenzaldehyde radical;Amlodipine Impurity T;OCBA(2-Chlorobenzaldehyde );o-Chlorobenzaldehyde 2-Chlorobenzaldehyde;ORTHO CHLORO BENZALDEHYDE;2-CHLOROBENZALDEHYDE, DIST.;2-ChlorobenzaldehydeForSynthesis;2-Chlorobenzaldehyde,>98%
CAS:	89-98-5
MF:	C7H5ClO
MW:	140.57
EINECS:	201-956-3
Product Categories:	Aromatics;Aromatic Aldehydes & Derivatives (substituted);C7Alphabetic;Aldehydes;C;Carbonyl Compounds;CH;C7;Pesticides intermediate;Pyridines;89-98-5
Mol File:	89-98-5.mol

2-Chlorobenzaldehyde Chemical Properties

Melting point	9-11 °C (lit.)
Boiling point	209-215 °C (lit.)
density	1.248 g/mL at 25 °C (lit.)
vapor density	4.84 (vs air)
vapor pressure	1.27 mm Hg ( 50 °C)
refractive index	n20/D 1.566(lit.)
Fp	190 °F
storage temp.	Store in RT
solubility	1.8g/l
form	Liquid
color	Clear colorless to light yellow
PH	2.9 (H2O)(saturated aqueous solution)
Water Solubility	0.1-0.5 g/100 mL at 24 ºC
Sensitive	Air Sensitive
BRN	385877
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, iron, strong reducing agents. Moisture and light-sensitive.
LogP	2.44 at 25℃
CAS DataBase Reference	89-98-5(CAS DataBase Reference)
NIST Chemistry Reference	Benzaldehyde, 2-chloro-(89-98-5)
EPA Substance Registry System	2-Chlorobenzaldehyde (89-98-5)

Safety Information

Hazard Codes	C,Xi
Risk Statements	34
Safety Statements	26-45
RIDADR	UN 3265 8/PG 3
WGK Germany	1
RTECS	CU5075000
F	8-9-23
Autoignition Temperature	746 °F
Hazard Note	Irritant
TSCA	Yes
HazardClass	8
PackingGroup	III
HS Code	29130000
Hazardous Substances Data	89-98-5(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 2160 mg/kg

MSDS Information

Provider	Language
2-Chlorobenzaldehyde	English
SigmaAldrich	English
ACROS	English
ALFA	English

2-Chlorobenzaldehyde Usage And Synthesis

Chemical Properties	2-Chlorobenzaldehyde is a colorless to yellowish liquid with a penetrating odor. Insoluble in water, soluble in benzene, alcohol and ether. 2-Chlorobenzaldehyde is considerably more resistant to oxidation than benzaldehyde. When it is heated with sodium sulfite solution under pressure, benzaldehyde-2-sulfonic acid forms.
Uses	2-Chlorobenzaldehyde has been used in generation of small focused library of diversely functionalized dihydropyrimidine derivatives via one-pot three-component Biginelli cyclocondensation of β-ketoesters, aldehydes and thioureas.
Uses	2-Chlorobenzaldehyde can be used to make alcohols, acids, and dyes; used in the rubber, tanning, and paper industries; used as an intermediate for optical brighteners, agricultural chemicals, and pharmaceuticals.It can also be used to prepare triphenyl methane and related dyes, organic intermediate.
Preparation	2-Chlorobenzaldehyde is produced mainly by chlorination of 2-chlorotoluene to form 2-chlorobenzal chloride, which is then subjected to acid hydrolysis. Metal salts, such as iron(III) chloride, are used as catalysts. The hydrolysis can also be accomplished using formic acid without a catalyst. 2-Chlorobenzaldehyde can also be produced by oxidation of 2-chlorobenzyl chloride with N-oxides of tertiary amines or with dilute nitric acid. https://pubchem.ncbi.nlm.nih.gov/compound/2-Chlorobenzaldehyde
Application	2-Chlorobenzaldehyde is used acid zinc plating brightener, also be used for organic synthesis, agricultural pesticide and pharmaceutical industries. It is used to synthesize the acaricides clofentezine and flutenzine. 2-Chlorobenzaldehyde undergoes alkynylation with phenylacetylene in the presence of catalytic ligands and dimethylzinc at 0°C to form binaphthyl-derived amino alcohols.
Synthesis Reference(s)	Tetrahedron Letters, 34, p. 8037, 1993 DOI: 10.1016/S0040-4039(00)61444-2
General Description	2-chlorobenzaldehyde is a clear colorless to yellowish liquid. (NTP, 1992)
Air & Water Reactions	2-Chlorobenzaldehyde is moisture and light sensitive. Slightly water soluble.
Reactivity Profile	2-Chlorobenzaldehyde reacts with iron and strong oxidizers, strong bases and strong reducing agents.
Health Hazard	Symptoms of exposure to 2-Chlorobenzaldehyde may include skin, eye and upper respiratory tract irritation. This compound may cause skin, eye and respiratory tract irritation. When heated to decomposition it emits toxic fumes.
Fire Hazard	2-Chlorobenzaldehyde is combustible.
Safety Profile	Poison by intraperitoneal and intravenous routes. When heated to decomposition it emits toxic fumes of Cl-. See also ALDEHYDES and CHLORIDES.
Purification Methods	Wash it with 10% Na2CO3 solution, then fractionally distil it in the presence of a small amount of catechol as stabiliser. [Beilstein 7 H 233, 7 IV 561.]

2-Chlorobenzaldehyde Preparation Products And Raw materials

Raw materials

Chlorine-->Zinc chloride-->Ferric chloride-->Dichloroethane-->Mercury-->2-Chlorotoluene-->2-Chlorobenzyl chloride-->2-Chlorobenzotrichloride-->BENZAL CHLORIDE-->3-Chlorotoluene-->3-CHLOROBENZAL CHLORIDE

Preparation Products

2-[4-(TERT-BUTYL)PHENOXY]-5-NITROBENZALDEHYDE-->Thianaphthene-2-carboxylic acid-->2-CHLORO-6-METHYLBENZALDEHYDE-->Clofentezine-->2-Chloro-5-nitrobenzaldehyde-->Amlodipine-->3-(2-Chlorophenyl)-5-methylisoxazole-4-carbonyl chloride-->3-(2-Chlorophenyl)-5-methylisoxazole-4-carboxylic acid-->ALIZARIN GREEN-->1-(2-chlorophenyl)-N-[(2-chlorophenyl)methylideneamino]methanimine-->2-CHLOROBENZALOXIME-->1-CHLORO-2-ETHYNYLBENZENE-->Tulobuterol-->N,N-bis(2-chlorobenzyl)amine-->1-Chloro-7-methylnaphthalene-->2-(2-chlorophenyl)-4,6-diphenyl-1,3,5-triazine-->2-Chlorobenzylamine-->ALIZARIN GREEN-->Benzenamine, 4-[(2-chlorophenyl)[4-(ethylimino)-3-methyl-2,5-cyclohexadien-1-ylidene]methyl]-N-ethyl-2-methyl-, hydrochloride (1:1)

2-Chlorophenylacetic acid 2-Chlorobenzoic acid 2-Chlorobenzonitrile 2-Chlorobenzoyl chloride 3-Chlorobenzaldehyde 2-Chlorophenol 2,6-Dichlorobenzaldehyde 1,5-DICHLOROANTHRAQUINONE 1-Chloro anthraquinone 2-(2-Chlorophenyl)acetonitrile 1,2,3-Trichlorobenzene 2,3-Dichlorobenzaldehyde 1,2,4-Trichlorobenzene 2,6-Dichlorobenzoyl chloride Chlorphenamine maleate 2,4-Dichlorobenzaldehyde 2-Chlorobenzaldehyde 2,4-Dichlorobenzoyl chloride

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2-Chlorobenzaldehyde

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