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| | 10,11-EDP epoxide Basic information |
| Product Name: | 10,11-EDP epoxide | | Synonyms: | 10,11-EDP epoxide;(±)10(11)-EDP Ethanolamide;4,7-Nonadienamide, N-(2-hydroxyethyl)-9-[3-(2Z,5Z,8Z)-2,5,8-undecatrien-1-yl-2-oxiranyl]-, (4Z,7Z)- | | CAS: | 2123484-71-7 | | MF: | C24H37NO3 | | MW: | 387.56 | | EINECS: | | | Product Categories: | | | Mol File: | 2123484-71-7.mol |  |
| | 10,11-EDP epoxide Chemical Properties |
| Boiling point | 568.7±50.0 °C(Predicted) | | density | 0.998±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml | | pka | 14.47±0.10(Predicted) |
| | 10,11-EDP epoxide Usage And Synthesis |
| Description | (±)10(11)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 0.43 and 22.5 nM for CB1 and CB2 receptors, respectively). It is produced though direct epoxygenation of docosahexaenoyl ethanolamide (DHEA; ) by cytochrome P450 (CYP) epoxygenases. 10,11-EDP epoxide (12.5 and 25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It induces apoptosis and inhibits cell migration in a wound-healing assay in 143B, MG63, and HOS osteosarcoma cells. (±)10(11)-EDP ethanolamide also reduces tube formation by human umbilical vein endothelial cells (HUVECs) in a Matrigel™ assay. |
| | 10,11-EDP epoxide Preparation Products And Raw materials |
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