PROPENTOFYLLINE

PROPENTOFYLLINE Basic information
Product Name:PROPENTOFYLLINE
Synonyms:3,7-DIHYDRO-3-METHYL-1-(5-OXOHEXYL)-7-PROPYL-1H-PURINE-2,6-DIONE;3-METHYL-1-[5-OXOHEXYL]-7-PROPYL-XANTHINE;PROPENTOFYLLINE;3,7-Dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-1H-purine-2,6-dione, HWA-285, Albert-285, HOE-285, Hextol, Karsivan;1H-Purine-2,6-dione, 3,7-dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-;HOE-285:Hextol:Karsivan;3-Methyl-1-(5-oxohexyl)-7-propylxanthine, HWA285, 3,7-Dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-1H-purine-2,6-dione;3-Methyl-1-(5-oxohexyl)-7-propylpurine-2,6-dione
CAS:55242-55-2
MF:C15H22N4O3
MW:306.36
EINECS:
Product Categories:All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:55242-55-2.mol
PROPENTOFYLLINE Structure
PROPENTOFYLLINE Chemical Properties
Melting point 64-66°C
Boiling point 541.4±56.0 °C(Predicted)
density 1.25±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility H2O: soluble12.4mg/mL
pka0.58±0.70(Predicted)
form solid
color white
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22
WGK Germany 3
RTECS UO8438700
ToxicityLD50 in male, female mice, male, female rats (mg/kg): 900, 780, 1150, 940 orally; 168, 170, 180, 195 i.v.; 375, 346, 199, 196 i.p.; 450, 508, 400, 338 s.c. (Inazu)
MSDS Information
PROPENTOFYLLINE Usage And Synthesis
DescriptionPropentofylline is a nootropic indicated for cerebrovascular disorders. Other indications currently under investigation include senile dementia, stroke and hypoxia.
Chemical PropertiesOff-White Solid
OriginatorHoechst AG (W.Germany)
UsesA c-AMP phosphodiesterase inhibitor. A nerve growth factor stimulator. An adenosine transport inhibitor. A non-selective adenosine receptor antagonist. Nootropic.
DefinitionChEBI: Propentofylline is an oxopurine.
Brand nameHextol
Biochem/physiol Actionsc-AMP phosphodiesterase inhibitor; nerve growth factor stimulator; adenosine transport inhibitor; non-selective adenosine receptor antagonist.
PROPENTOFYLLINE Preparation Products And Raw materials
Raw materials1-Bromo-5-hexanone
Tiopronin 3-ETHYL-3H-IMIDAZOLE-4-CARBALDEHYDE Propentofylline-d6 1-N-HEXYLTHEOBROMINE 1-N-BUTYL-3,7-DIMETHYLXANTHINE Theophylline Pentoxifylline 1-N-PROPYL-3,7-DIMETHYLXANTHINE 7-ETHYL THEOPHYLLINE 3-Methyl-7-propylxanthine CAFFEINE PROPENTOFYLLINE

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