ChemicalBook Product Catalog Chemical Reagents Organic reagents Boric acid 2-Bromophenylboronic acid

2-Bromophenylboronic acid

2-Bromophenylboronic acid Basic information
Product Name:2-Bromophenylboronic acid
Synonyms:2-broMoborate;o-BBBA;2-Bromophenylboronic acid >=95.0%;Boronic acid,B-(2-bromophenyl)-;AKOS BRN-0929;RARECHEM AH PB 0074;O-BROMOPHENYLBORONIC ACID;2-BROMOPHENYLBORONIC ACID
CAS:244205-40-1
MF:C6H6BBrO2
MW:200.83
EINECS:678-199-4
Product Categories:Boronic Acids and Derivatives;Boronate Ester;Boronic Acid;Potassium Trifluoroborate;Pyridines;blocks;BoronicAcids;Bromides;B (Classes of Boron Compounds);Boronic Acids;Aryl;Boronic Acids
Mol File:244205-40-1.mol
2-Bromophenylboronic acid Structure
2-Bromophenylboronic acid Chemical Properties
Melting point 113 °C(lit.)
Boiling point 329.2±44.0 °C(Predicted)
density 1.67±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly)
form Powder
pka8.25±0.58(Predicted)
color White to off-white
Water Solubility Soluble in methanol. Slightly soluble in water.
BRN 8542615
CAS DataBase Reference244205-40-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 36/37/38-22
Safety Statements 37/39-26
WGK Germany 3
HazardClass IRRITANT
HS Code 29319090
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
2-Bromophenylboronic acid Usage And Synthesis
Chemical PropertiesWhite to off-white powder
Uses2-Bromobenzeneboronic acid is a boronic acid derivative that is widely used in organic synthesis for carbon-carbon bond formation. In Suzuki coupling, aryl halides and boronic acid aryl or vinyl esters or boronic acids are coupled using Pd(PPh3)4.
Application2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
Catalyzes the formation of amide bonds from amines and carboxylic acids.
Used to promote greener amidations of carboxylic acids and amines in catalytic amounts. This technology avoids the requirement of preactivation of the carboxylic acid or use of coupling reagents.
It is also an important intermediate for Organic Light-Emitting Diod ( OLED) .
Preparation2-Bromophenylboronic acid synthesis: take 2-bromoaniline as raw material, synthesize the intermediate 1-Bromo-2-iodobenzene through diazotization and iodination, and then carry out magnesium iodide exchange with isopropylmagnesium bromide to synthesize o-bromophenylmagnesium bromide, It is then subjected to substitution reaction with trimethyl borate to synthesize methyl o-bromophenylboronic acid, and then hydrolyzed to synthesize 2-bromophenylboronic acid.
2-BROMO-6-FLUOROPHENYLBORONIC ACID 2-BROMOPHENYLBORONIC ACID PINACOL ESTER 2-BROMO-4,5-DIFLUOROPHENYLBORONIC ACID 2-BROMO-6-FLUORO-3-ISOPROPOXYPHENYLBORONIC ACID 2-BROMO-5-METHOXYPHENYLBORONIC ACID Ascoric Acid Phenylacetone 6-BROMO-3-BUTOXY-2-FLUOROPHENYLBORONIC ACID 2-Bromo-6-fluoro-3-methoxyphenylboronic acid (2,6-DIBROMO-5-METHOXY)BENZENEBORONIC ACID 2-BROMO-5,6-DIFLUOROPHENYLBORONIC ACID 2-BROMO-3-ETHOXY-6-FLUOROPHENYLBORONIC& 2-CYANO-5-BROMOPHENYLBORONIC ACID PINACOL ESTER 2-Fluoro-3-ethoxy-6-bromophenylboronic acid 2-BROMO-3-BUTOXY-6-FLUOROPHENYLBORONIC ACID (2,4-DIBROMO-5-METHOXY)BENZENEBORONIC ACID 1-BROMO-2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZENE 2-Fluoro-5-bromophenylboronic acid
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