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| Product Name: | cis-1,2-Diaminocyclohexane | | Synonyms: | (R)(S)-1,2-Diaminocyclohexane;1,2-Cyclohexanediamine, cis-;cis-1,2-Cyclohexandiamine;meso-1,2-Cyclohexanediamine;CIS-1,2-DIAMINOCYCLOHEXANE;CIS-1,2-CYCLOHEXANEDIAMINE;(1R,2S)-1,2-Cyclohexanediamine;(±)-cis-1,2-Diaminocyclohexane,97% | | CAS: | 1436-59-5 | | MF: | C6H14N2 | | MW: | 114.19 | | EINECS: | 205-754-6 | | Product Categories: | | | Mol File: | 1436-59-5.mol |  |
| | cis-1,2-Diaminocyclohexane Chemical Properties |
| Melting point | 8°C | | Boiling point | 92-93 °C/18 mmHg (lit.) | | density | 0.952 g/mL at 25 °C (lit.) | | vapor pressure | 0.4 mm Hg ( 20 °C) | | refractive index | n20/D 1.493(lit.) | | Fp | 161 °F | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | Water Solubility | Completely miscible in water | | form | Low Melting Solid | | pka | 9.93(at 20℃) | | color | Brown | | InChIKey | SSJXIUAHEKJCMH-OLQVQODUSA-N | | CAS DataBase Reference | 1436-59-5(CAS DataBase Reference) | | NIST Chemistry Reference | cis-1,2-Cyclohexanediamine(1436-59-5) |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 2735 8/PG 2 | | WGK Germany | 3 | | F | 10-34 | | HazardClass | 8 | | PackingGroup | II | | HS Code | 29213000 |
| | cis-1,2-Diaminocyclohexane Usage And Synthesis |
| Description | cis-1, 2-Diaminocyclohexane is a cyclohexane derivative. It can be used for the synthesis of platinum complexes with high antitumor activity. It can also be used for the preparation of multidentate ligands for uranyl and transition metal complexation. Moreover, it can also be used as the base for the manufacturing of titanium salalen catalyst. Its derivative also has the potential to be manufactured into a potent factor Xa inhibitor.
| | References | Khokhar, Abdul R., et al. "Chemical and Biological Studies on a Series of Novel (trans-(1R,2R)-, trans-(1S,2S)-, and cis-1,2-Diaminocyclohexane)platinum(IV) Carboxylate Complexes." Journal of Medicinal Chemistry 40.1(1997):112.
Mauldin, S. K., et al. "High-performance liquid chromatographic separation of platinum complexes containing the cis-1,2-diaminocyclohexane carrier ligand. " Analytical Biochemistry157.1 (1986):129-43.
Berkessel, A, et al. "Titanium salalen catalysts based on cis-1,2-diaminocyclohexane: enantioselective epoxidation of terminal non-conjugated olefins with H2O2. " Angewandte Chemie 52.32(2013):8467-71.
Yoshikawa, K, et al. "Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: exploration of 5-6 fused rings as alternative S1 moieties. " Bioorganic & Medicinal Chemistry 17.24(2009):8221.
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| | Chemical Properties | Clear colorless liquid | | Uses | cis-1,2-Diaminocyclohexane was used in the synthesis of platinum complexes that have high antitumor activity.It was also used in the synthesis of multidentate ligands for uranyl and transition metal complexation. | | General Description | cis-1,2-Diaminocyclohexane perturbed the spectrum of free pyrroloquinoline quinone (PQQ), a covalently linked form of which is the carbonyl cofactor of lysyl oxidase and also induced similar changes in the spectrum of lysyl oxidase. | | Purification Methods | Dry the diamine over solid KOH and distil it in a vacuum. It is a strong base, keep away from CO2, store in the dark under N2. [Beilstein 13 IV 1.] |
| | cis-1,2-Diaminocyclohexane Preparation Products And Raw materials |
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