ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Glutamine derivatives Transglutaminase

Transglutaminase

Transglutaminase Basic information
Product Name:Transglutaminase
Synonyms:EC 2.3.2.13;FACTOR XIII-A, HUMAN;PROTEIN-GLUTAMINE: AMINE GAMMA-GLUTAMYLTRANSFERASE;akuthibatg;akuthibatg-k;glutaminylpeptidegamma-glutamyltransferas;glutaminylpeptidegammaglutamyltransferase;Glutamine transaminase
CAS:80146-85-6
MF:C27H44O3H2O
MW:0
EINECS:232-554-6
Product Categories:
Mol File:Mol File
Transglutaminase Structure
Transglutaminase Chemical Properties
storage temp. -20°C
solubility H2O: soluble1.0mg/mL, clear
form lyophilized powder
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 22-24/25-26
WGK Germany 1
RTECS MA2370000
F 10
MSDS Information
ProviderLanguage
SigmaAldrich English
Transglutaminase Usage And Synthesis
Usestransglutaminase is an enzyme said to activate the skin’s physiological functions.
UsesTransglutaminase has been used in a study to improve quantifiable assays to fully characterize the role of transglutaminase in diseases such as Huntington′s disease and Alzheimer′s disease.Transglutaminase has also been used in a study to develop a nonradioactive dot blot assay for transglutaminase activity.
Biochem/physiol ActionsTransglutaminase from guinea pig liver consists of a single polypeptide chain of 691 amino acid residues. It has six potential glycosylation sites (Asn-X-Ser or Asn-X-Thr), but it is not glycosylated. The molecular mass is approximately 76.6 kDa. It is calcium dependent and has several calcium binding sites. The enzyme is inhibited by iodoacetamide and N-ethylmaleimide in the presence of calcium. It catalyzes the incorporation of small molecular weight amines into γ-glutamine sites of proteins. In the absence of small molecular weight amines, it catalyzes the cross linking of proteins that results in the formation of γ-glutamyl-ε-lysine side chain peptides. Liver transglutaminase is a nonzymogenic enzyme.
Transglutaminase Preparation Products And Raw materials
Raw materialsstreptomyces avermifilis
Aluminum acetylacetonate METHYL ISOCYANOACETATE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) N-BUTYLISOCYANIDE PHENYLSELENOL DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) SALCOMINE 2,4-PENTANEDIONE, SILVER DERIVATIVE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tosylmethyl isocyanide COBALT(II) ACETYLACETONATE Cupric acetylacetonate Ethyl isocyanoacetate TERT-BUTYL ISOCYANIDE Ferric acetylacetonate COBALT ETHYLENE DIAMINE CHLORIDE Benzyl isocyanide TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)
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