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| Product Name: | DOTA | | Synonyms: | TETRAAZA-12-CROWN-4 TETRAACETIC ACID AMMONIUM SALT (SEE 2923);Tetraxetan/radical;1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrakisacetic acid;2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetryl)tetraacetic acid;2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetryl)tetrakisacetic acid;1,4,7,10-TETRAAZACYCLODODECANE-N,N'',N , N''-TETRAACETIC ACID , (DOTA);1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID DOTA;DOTA(M-140) | | CAS: | 60239-18-1 | | MF: | C16H28N4O8 | | MW: | 404.42 | | EINECS: | 611-959-5 | | Product Categories: | Achiral Nitrogen;Cy-N;Azacrown Ethers;Functional Materials;Macrocycles for Host-Guest Chemistry;60239-18-1 | | Mol File: | 60239-18-1.mol |  |
| Melting point | 267 °C | | Boiling point | 701.6±60.0 °C(Predicted) | | density | 1.321 | | storage temp. | Sealed in dry,Room Temperature | | solubility | Water (Slightly, Heated), Methanol (Slightly) | | pka | 2.16±0.10(Predicted) | | form | Powder | | color | white | | BRN | 1186987 | | Stability: | Hygroscopic |
| Chemical Properties | Colourless crystals | | Uses | Bifunctional DOTA aconjugates to peptides and has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and ther
apeutic radiopharmaceuticals. | | Uses | 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a macrocyclic complexing agent.
- It has been used for radiolabeling of carbon nanotube bioconjugates by chelating 64Cu radioisotope.
- DOTA can be activated with N-hydroxysulfosuccinimidyl for conjugation with monoclonal antibodies in clinical radioimmunotherapy.
- It can form complexes with gadolinium for application as MRI contrast agents.
- Metal complexes of DOTA-peptide conjugates can be used as therapeutic radiopharmaceuticals.
| | Definition | ChEBI: An azamacrocyle in which four nitrogen atoms at positions 1, 4, 7 and 10 of a twelve-membered ring are each substituted with a carboxymethyl group. |
| | DOTA Preparation Products And Raw materials |
| Raw materials | Iodoacetic acid potassium salt-->1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7-tris(1-methyl-1-phenylethyl) ester-->SODIUM BROMOACETATE-->TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD-->2-PHENYL-2-PROPANOL-->Cyclen-->IODOACETIC ACID SODIUM SALT-->Bromoacetic acid-->Iodoacetic acid-->Sodium chloroacetate-->Ethyl bromoacetate-->Methyl bromoacetate | | Preparation Products | 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester |
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