ChemicalBook Product Catalog Organic Chemistry Heterocyclic Compounds 1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINONE

1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINONE

1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINONE Basic information
Product Name:1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINONE
Synonyms:N-BOC-1-AZACYCLOPENTAN-2-ONE;TERT-BUTYL 2-OXOPYRROLIDINE-1- CA;CAS_85909-08-6;1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINONE;2-OXO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;AIDS143102;tert-Butyl 2-oxo-1-pyrrolidinecarboxylate;Pyrrolidin-2-one, N-BOC protected
CAS:85909-08-6
MF:C9H15NO3
MW:185.22
EINECS:
Product Categories:NSC 662770;Building Blocks;Building Blocks;C4 to C10;Chemical Synthesis;Heterocyclic Building Blocks;Heterocyclic Building Blocks;Pyrrolidines;other
Mol File:85909-08-6.mol
1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINONE Structure
1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINONE Chemical Properties
Boiling point 100-105 °C/0.5 mmHg(lit.)
density 1.086 g/mL at 25 °C(lit.)
refractive index n20/D 1.466(lit.)
Fp 113 °C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform, Methanol
pka-2.21±0.20(Predicted)
form Oil
color Clear Colorless to Brown
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
HS Code 2933790090
MSDS Information
1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINONE Usage And Synthesis
UsesN-Boc-2-pyrrolidinone is a useful synthetic intermediate. It can be used to prepare highly functionalized N-acyl-2-vinylpyrrolidines by a 4-component Ugi reaction (isocyanide, carbonyl compounds, primary amines, carboxylic acids). It can also be used to synthesize the naturally occurring Maillard flavors via catalytic SeO2 oxidation.
General DescriptionThe kinetics of gas-phase elimination of 1-(tert-butoxycarbonyl)-2-pyrrolidinone has been investigated in a static system. The observed rate coefficient has been reported to be log k1(s-1) = (11.54 ± 0.29) -(140.8 ± 2.8)-kJmol-1 (2.303RT)-1.
1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINONE Preparation Products And Raw materials
Preparation Products2-Boc-7-oxo-2-Azaspiro[4.4]nonane-->N-BOC PRROLIDIN-2-OL-->Carbamic acid, N-[4-(3-fluorophenyl)-4-oxobutyl]-, 1,1-dimethylethyl ester-->(2E)-6-[[(1,1-DiMethylethoxy)carbonyl]aMino]-2-hexenoic Acid Ethyl Ester
BOC-PYR-OH DCHA BOC-PYR-OH SPECS AQ-405/42300449 BOC-PYR-OET BENZYL-N-BOC-L-PYROGLUTAMATE BOC-(2S, 3R)-PYROGLUT[3-(4-HYDROXYPHENYL)] (4S,5S)-N-BOC-5-(2-METHYL-1-PROPYL)-4-HYDROXY-2-PYRROLIDINONE (2S,4R)-BENZYL-BOC-GAMMA-(2-NAPHTHYLMETHYL)-PYROGLUTAMATE (2S,4R)-BENZYL-BOC-GAMMA-(4-BROMOBENZYL)-PYROGLUTAMATE (4R)-BOC-4-(4-METHYLBENZYL)-PYR-OBZL (2S,4R)-BENZYL-BOC-GAMMA-BENZYLPYROGLUTAMATE BOC-(2S, 3S)-PYROGLUT(3-ME) BOC-(2S, 3S)-PYROGLUT(3-CF3) (S)-N-(tert-Butoxycarbonyl)-2-pyrrolidinone-5-carboxylic acid methyl (4R)-BOC)-4-BENZYL-PYR-OBZL (S)-N-ALPHA-T-BUTYLOXYCARBONYL-PYROGLUTAMIC ACID T-BUTYL ESTER 1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINONE (4R)-BOC-4-BENZYL-PYR-OH
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