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| | Lorazepam Basic information |
| Product Name: | Lorazepam | | Synonyms: | 8133 CB;7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepine-2-one;Lorazepam CIV (200 mg);Acetonitrile( Test Lorazepam, 1.0 mg/mL );LorazepaM (CIV), USP;(+-)-lorazepammethanolsolution;1,4-benzodiazepin-2-one,7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2;2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy- | | CAS: | 846-49-1 | | MF: | C15H10Cl2N2O2 | | MW: | 321.16 | | EINECS: | 212-687-6 | | Product Categories: | API's;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labeled Compounds | | Mol File: | 846-49-1.mol |  |
| | Lorazepam Chemical Properties |
| Melting point | 166-168°C | | Boiling point | 533.8±50.0 °C(Predicted) | | density | 1.4835 (rough estimate) | | refractive index | 1.6070 (estimate) | | Fp | 11 °C | | storage temp. | −20°C | | solubility | Practically insoluble in water, sparingly soluble in ethanol (96 per cent), sparingly soluble or slightly soluble in methylene chloride. | | pka | pK1 1.3; pK2 11.5(at 25℃) | | Water Solubility | 54mg/L(temperature not stated) | | BCS Class | 1 | | Stability: | hygroscopic | | CAS DataBase Reference | 846-49-1(CAS DataBase Reference) | | NIST Chemistry Reference | Lorazepam(846-49-1) | | EPA Substance Registry System | Lorazepam (846-49-1) |
| | Lorazepam Usage And Synthesis |
| Chemical Properties | White Crystalline Solid | | Originator | Tavor,Wyeth,Italy,1972 | | Uses | An anxiolytic, and anticonvulsant.
Controlled substance (depressant) | | Definition | ChEBI: Lorazepam is a benzodiazepine. | | Manufacturing Process | The starting material was 2-amino-2',5-dichlorobenzophenone which was
reacted with hydroxylamine and then with chloroacetyl chloride. The
intermediate thus obtained is reacted with methylamine and then with acetic
anhydride.
To a slightly warm suspension of 3-acetoxy-7-chloro-5-(o-chlorophenyl)-1,3-
dihydro-2H-1,4-benzodiazepin-2-one thus obtained was added 4N sodium
hydroxide solution with stirring. All the solid dissolved and soon a thick white
solid precipitated out. The solid was filtered, washed well with water and
recrystallized from ethanol. The product was isolated as a solvate with 1 mol
of ethanol. When heated it loses the ethanol of solvation and melts at 166°C
to 168°C. | | Brand name | Ativan (Baxter Healthcare); Ativan
(Biovail); Loraz (Quantum Pharmics). | | Therapeutic Function | Tranquilizer | | General Description | Lorazepam, 7-chloro-5-(2-chlorophenyl)-3-dihydro-3-hydroxy-2H-1,4-benzodiazepine-2-one(Ativan), is the 2'-chloro derivative of oxazepam. In keepingwith overall SARs, the 2'-chloro substituent increases activity.As with oxazepam, metabolism is relatively rapid anduncomplicated because of the 3-hydroxyl group in the compound.Thus, it also has short half-life (2–6 hours) and similarpharmacological activity. | | Biological Activity | Ligand at the GABA A receptor benzodiazepine modulatory site. Anxiolytic, anticonvulsant and sedative/hypnotic agent. |
| | Lorazepam Preparation Products And Raw materials |
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