Benzethonium chloride

Benzethonium chloride Basic information
Product Name:Benzethonium chloride
Synonyms:2-phenylethyliuM chloride;BENZETHONIUM CHLORIDE EP;BenzethoniuM chloride, 97% 100GR;BenzethoniuM chloride, 97% 500GR;2-(2-(p-(Diisobutyl)phenoxy)ethoxy)ethyldiMethylbenzylaMMoniuM Chlor;1622;HyaMine®;N-benzyl-N,N-diMethyl-2-(2-(4-(2,4,4-triMethylpentan-2-yl)phenoxy)ethoxy)ethanaMiniuM chloride
CAS:121-54-0
MF:C27H42ClNO2
MW:448.08
EINECS:204-479-9
Product Categories:Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;PHEMERIDE;Organics;Ammonium Chlorides (Quaternary);Aromatic Quaternary Ammonium Salts (Surfactants);Cationic Surfactants;Functional Materials;Quaternary Ammonium Compounds;Surfactants;Anti-virals;121-54-0
Mol File:121-54-0.mol
Benzethonium chloride Structure
Benzethonium chloride Chemical Properties
Melting point 162-164 °C (lit.)
Boiling point 162℃[at 101 325 Pa]
density 0.998 g/mL at 20 °C
vapor pressure < 0.001 hPa @ 2°C
refractive index 1.5650 (estimate)
storage temp. 2-8°C
solubility H2O: 0.1 M at 20 °C, clear, colorless
form Liquid
color White
PH5.5-7.5 (25℃, 0.1M in H2O)
OdorOdorless
PH Range5.5 - 7.5
Water Solubility 1-5 g/100 mL at 18 ºC
Sensitive Hygroscopic
Merck 14,1074
BRN 3898548
Stability:Stability Stable, but hygroscopic. Incompatible with strong oxidizing agents, soap, anionic detergents, nitrates, acids. Light sensitive.
LogP1.08 at 20℃
CAS DataBase Reference121-54-0(CAS DataBase Reference)
EPA Substance Registry SystemBenzethonium chloride (121-54-0)
Safety Information
Hazard Codes Xn,N,C
Risk Statements 22-37/38-41-36-36/37/38-20/21/22-50/53-34-52/53
Safety Statements 26-36/39-24/25-36/37/39-61-45
RIDADR UN1759
WGK Germany 2
RTECS BO7175000
8
TSCA Yes
HazardClass 8
PackingGroup III
HS Code 29239000
Hazardous Substances Data121-54-0(Hazardous Substances Data)
ToxicityLD50 i.v. in mice: 29.5 mg/kg (Weiss)
MSDS Information
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Benzethonium chloride English
SigmaAldrich English
ACROS English
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Benzethonium chloride Usage And Synthesis
Chemical PropertiesWhite or yellowish-white powder.
Chemical PropertiesBenzethonium chloride occurs as a white crystalline material with a mild odor and very bitter taste.
OriginatorPhemerol,Parke Davis,US,1942
UsesA synthetic quaternary ammonium salt with surfactant, antiseptic and anti-infective properties. It exhibits microbiocidal activity against a broad range of bacteria, fungi, mold and viruses. It has al so been found to have significant broad-spectrum anticancer activity.
UsesHyamine(R) 1622 Crystals is a FDA accepted ingredient for topical applications. It can be used as a bactericide, deodorant, or as a preservative in various applications including those in personal care, veterinary and pharmaceutical.
Usesbenzethonium chloride is a preservative that works against algae, bacteria, and fungi. In skin care preparations, it is safe for use at concentrations of 0.5 percent.
Usesantiinfective (topical)
UsesThe cationic detergent benzethonium chloride is a well characterized skin irritant and rare sensitizer. Benzethonium chloride has been used in a study to assess the minimum inhibitory concentrations of meticillin-resistant Staphylococcus aureus (MRSA) isolates from Malaysia. It has also been used in a study to prepare biocomposite films from sodium alginate and modified clay.
UsesIn cosmetics as preservative; cationic surfactant. As disinfectant in dairies and food industries. Clinical reagent for determination of protein in CSF; pharmaceutic aid (preservative).
UsesBenzethonium Chloride USP is used as germicide for pharmaceutical and cosmetic products. (USP grade of Hyamine(R) 1622 crystals).
DefinitionChEBI: A (synthetic) quaternary ammonium salt that is benzyldimethylamine in which the nitrogen is quaternised by a 2-{2-[p-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethyl group, with chloride as the counter-ion. An antiseptic and disinfectant, it i active against a broad spectrum of bacteria, fungi, moulds and viruses.
Production Methodsp-Diisobutylphenol is condensed in the presence of a basic catalyst with β,β'-dichlorodiethyl ether to yield 2-[2-[4-(1,1,3,3-tetramethylbutyl) phenoxy]ethoxy]ethyl chloride. Alkaline dimethylamination then produces the corresponding tertiary amine which, after purification by distillation, is dissolved in a suitable organic solvent and treated with benzyl chloride to precipitate benzethonium chloride.
Manufacturing ProcessA mixture of 32 g of p-(α,α,γ,γ-tetramethylbutyl)phenoxyethoxyethyldimethylamine and 12.7 parts of benzyl chloride was warmed in 50 g of benzene for 2 hours. The benzene was then evaporated. The residual viscous mass gave a foamy, soapy solution in water. The original starting materials are p-diisobutylphenol, dichlorodiethyl ether and dimethylamine.
Brand nameMicroklenz (Carrington); Phemerol Chloride (Parke-Davis).
Therapeutic FunctionTopical antiinfective
General DescriptionOdorless white crystals or powder with a very bitter taste. A 1% solution in water is slightly alkaline to litmus.
Air & Water ReactionsHygroscopic. May be sensitive to prolonged exposure to air. Water soluble.
Reactivity ProfileBenzethonium chloride is incompatible with strong oxidizing agents Incompatible with soap and anionic detergents. Can react with nitrates. Sensitive to light. Acids cause Benzethonium chloride to precipitate from aqueous solutions of >2% concentration. Stable for two weeks at temperatures up to 140 F, .
HazardAn oral poison.
Fire HazardFlash point data for Benzethonium chloride are not available. Benzethonium chloride is probably combustible.
Flammability and ExplosibilityNotclassified
Pharmaceutical ApplicationsBenzethonium chloride is a quaternary ammonium compound used in pharmaceutical formulations as an antimicrobial preservative. Typically, it is used for this purpose in injections, ophthalmic and otic preparations at concentrations 0.01–0.02% w/v. Benzethonium chloride may also be used as a wetting and solubilizing agent, and as a topical disinfectant.
In cosmetics such as deodorants, benzethonium chloride may be used as an antimicrobial preservative in concentrations up to 0.5% w/v.
The physical properties and applications of benzethonium chloride are similar to those of other cationic surfactants such as cetrimide.

Safety ProfilePoison by ingestion,subcutaneous, intraperitoneal, and intravenous routes. Asevere eye irritant. Questionable carcinogen withexperimental neoplastigenic data. Mutation data reported.When heated to decomposition it emits very toxic fumesof Cl -
SafetyBenzethonium chloride is readily absorbed and is generally regarded as a toxic substance when administered orally. Ingestion may cause vomiting, collapse, convulsions, and coma. The probable lethal human oral dose is estimated to be 50–500 mg/kg bodyweight.
The topical use of solutions containing greater than 5% w/v benzethonium chloride can cause irritation although benzethonium chloride is not regarded as a sensitizer. The use of 0.5% w/v benzethonium chloride in cosmetics is associated with few adverse effects. A maximum concentration of 0.02% w/v benzethonium chloride is recommended for use in cosmetics used in the eye area and this is also the maximum concentration generally used in pharmaceutical formulations such as injections and ophthalmic preparations.
See also Benzalkonium Chloride.
LD50 (mouse, IP): 15.5 mg/kg
LD50 (mouse, IV): 30 mg/kg
LD50 (mouse, oral): 338 mg/kg
LD50 (rat, IP): 16.5 mg/kg
LD50 (rat, IV): 19 mg/kg
LD50 (rat, oral): 368 mg/kg
LD50 (rat, SC): 119 mg/kg






storageBenzethonium chloride is stable. Aqueous solutions may be sterilized by autoclaving.
The bulk material should be stored in an airtight container protected from light, in a cool, dry place.
Purification MethodsCrystallise it from boiling acetone after filtering or from CHCl3/pet ether. The precipitate is filtered off, washed with diethyl ether and dried for 24hours in a vacuum desiccator. It is a cationic antiseptic surfactant which forms crystals also from a 1:9 MeOH/Et2O mixture. It foams in water. [Beilstein 12 IV 2187.]
IncompatibilitiesBenzethonium chloride is incompatible with soaps and other anionic surfactants and may be precipitated from solutions greater than 2% w/v concentration by the addition of mineral acids and some salt solutions.
Regulatory StatusIncluded in the FDA Inactive Ingredients Database (IM and IV injections; nasal, ophthalmic and otic preparations). Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Benzethonium chloride Preparation Products And Raw materials
Raw materialsSodium hydroxide-->Toluene-->Benzene-->Benzyl chloride-->Dimethylamine-->4-tert-Octylphenol-->2,2'-Dichlorodiethyl ether-->4-Butylphenol
Benzyldodecyldimethylammonium bromide Dimethylbenzylcarbinyl acetate phenoxybenzamine BENZETHONIUM CHLORIDE(REAGENT / STANDARD GRADE) Benzyltriethylammonium chloride BENZETHONIUM CHLORIDE CRYSTA 4-Ethoxyphenol BENZALKONIUM CHLORIDE BENZETHONIUM CHLORIDE EPB(CRM STANDARD) Benzyltrimethylammonium chloride Ethoxyquin BENZETHONIUM CHLORIDE 98%,BENZETHONIUM CHLORIDE(RG),BENZETHONIUM CHLORIDE H2O,BENZETHONIUM CHLORIDE MONOHYDRATE ISOXADIFEN-ETHYL Ethoxy METHYL BENZETHONIUM CHLORIDE acetic acid, triethoxy-, ethyl ester Thionyl chloride 2-​[[(2-​ethylphenyl)​(2-​hydroxyethyl)​amino]​methyl]​-​3,​3-​difluoro-Propanenitrile

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