|
| | GANODERIC ACID A Basic information |
| Product Name: | GANODERIC ACID A | | Synonyms: | (25R)-7β,15α-Dihydroxy-3,11,23-trioxo-5α-lanost-8-en-26-oic acid;Aids070759;Aids-070759;Lanost-8-en-26-oic acid, 7,15-dihydroxy-3,11,23-trioxo-, (7.beta.,15.alpha.,25R)-;(7beta,15alpha,25R)-7,15-Dihydroxy-3,11,23-trioxo-lanost-8-en-26-oic acid;GANODERIC ACID A(P);GANODERIC ACID A;(25R)-7β,15α-Dihydroxy-3,11,23-trioxo-5α-lanost-8-en-26-oicaci | | CAS: | 81907-62-2 | | MF: | C30H44O7 | | MW: | 516.67 | | EINECS: | | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 81907-62-2.mol |  |
| | GANODERIC ACID A Chemical Properties |
| Melting point | 118～123℃ | | Boiling point | 690.1±55.0 °C(Predicted) | | density | 1.22 | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | Chloroform (Slightly, Sonicated), Methanol (Slightly) | | pka | 4.78±0.23(Predicted) | | form | Solid | | color | White to Pale Yellow |
| Safety Statements | 24/25 | | HS Code | 29189900 |
| | GANODERIC ACID A Usage And Synthesis |
| Description | Ganoderic acid A is a triterpene that has been found in Ganoderma and has diverse biological activities. It reduces cell viability, expression of superoxide dismutase 1 (SOD1), SOD2, and SOD3, and production of reactive oxygen species (ROS) in PC3 prostate cancer cells. Ganoderic acid A (2-100 μg/ml) reduces hypoxia-induced apoptosis in H9c2 cardiomyocytes. It inhibits LPS-induced activation of NF-κB, release of TNF-α, IL-1β, and IL-6, and mitochondrial activity in primary mouse cortical microglia. Ganoderic acid A (20 and 40 mg/kg) reduces lung myeloperoxidase (MPO) activity, neutrophil infiltration, and NF-κB signaling, as well as bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-1β, and IL-6 in a mouse model of LPS-induced lung injury. It also reduces weight gain and hepatic lipid accumulation and improves insulin sensitivity in a mouse model of high-fat diet-induced obesity. | | Chemical Properties | White powder | | Uses | Ganoderic Acid A, is a new lanostanoid triterpene extracted from the fruit bodies of Ganoderma Lucidum mushroom. these compounds are shown to possess many therapeutic properties. They can be used as anti-virus, anti-inflammation, anti-tumor, immunity-promoting, anti-diabetic, etc. | | Definition | ChEBI: Ganoderic acid A is a triterpenoid. |
| | GANODERIC ACID A Preparation Products And Raw materials |
|
