D(+)-Malic acid

D(+)-Malic acid Basic information
Product Name:D(+)-Malic acid
Synonyms:Butanedioic acid, hydroxy-, (R)-;hydroxy-,(R)-Butanedioicacid;l(+)-malicaci;(R)-(+)-MALIC ACID;(+)-D-MALIC ACID;D-(+)-APPLE ACID;D-APPLE ACID;MALIC ACID, D-(+)-
CAS:636-61-3
MF:C4H6O5
MW:134.09
EINECS:211-262-2
Product Categories:Chiral Compound;Aliphatics;Chiral Reagents;FINE Chemical & INTERMEDIATES;Food & Feed ADDITIVES;MalicAcidSeries;chiral;API intermediates;All Aliphatics;Carboxylic Acids (Chiral);Chiral Building Blocks;for Resolution of Bases;Optical Resolution;Synthetic Organic Chemistry;CHIRAL CHEMICALS;Chiral chemicals
Mol File:636-61-3.mol
D(+)-Malic acid Structure
D(+)-Malic acid Chemical Properties
Melting point 98-102 °C (lit.)
Boiling point 167.16°C (rough estimate)
alpha 2.2 º (c=3, H2O)
density 1.60
refractive index 6.5 ° (C=10, Acetone)
storage temp. Store below +30°C.
solubility Soluble in methanol, ethanol, acetone, ether.
pka3.61±0.23(Predicted)
form Crystalline Powder
color White
PH2.2 (10g/l, H2O, 20℃)
optical activity[α]20/D +28.0±2°, c = 5.5% in pyridine
Water Solubility soluble
Merck 14,5707
BRN 1723540
LogP-1.370 (est)
CAS DataBase Reference636-61-3(CAS DataBase Reference)
NIST Chemistry Reference(r)-Hydroxybutanedioic acid(636-61-3)
Safety Information
Hazard Codes Xi
Risk Statements 37/38-41-36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
RTECS ON7260000
HS Code 29181980
MSDS Information
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D(+)-Malic acid Usage And Synthesis
Chemical Propertieswhite to light yellow crystal powde
UsesD-(+)-Malic acid can be used:
  • As a starting material for the enantioselective total synthesis of (?)-erinapyrone B.
  • As a chiral organocatalyst in the synthesis of α-aminophosphonates from various aldehydes, aniline, and diethyl phosphite.

UsesThe naturally occuring isomer is the L-form which has been found in apples and many other fruits and plants. Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid rece
UsesD-(+)-Malic acid used as an acidulant and flavoring agent, food additive. And it is also used in the place of the less sour citric acid in sour sweets.
DefinitionChEBI: An optically active form of malic acid having (R)-configuration.
Biological ActivityD-(+)-Malic acid, an active isomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport.
SynthesisMalic acid is isolated from immature apples; industrially prepared is obtained by catalytic oxidation of benzene, then reacting with water at high temperature and high pressure to generate maleic anhydride.
in vitroSome bacteria belonging to Arthrobacter, Brevibacterium, Corynebacterium, Pseudomonas, Bacillus, and Acinetobacter produced D-(+)-Malic acid (D-Malic acid) from Maleic acid when the cells grown in a medium containing citraconic acid are reacted aerobically with Maleic acid in the pH 7.0 phosphate buffer containing 0.1% sodium chloride.
Sunitinib Malate Ethyl 2-(Chlorosulfonyl)acetate POTASSIUM TARTRATE Ascoric Acid (S)-(+)-ISOPROTERENOL L(+)-BITARTRATE L-Arginine DL-Malate(2:1) Dimethyl malate DL-MALIC ACID DISODIUM SALT L-(+)-TARTARIC ACID DI-N-BUTYL ESTER CALCIUM MALONATE Dibenzoyltartaric acid SODIUM DIHYDROXYTARTRATE L-HYDROXYBUTANEDIOIC ACID DISODIUM SALT Calcium citrate malate Diethyl succinosuccinate L(-)-MALIC ACID DISODIUM SALT MONOHYDRATE ZINC ZIRCONATE LITHIUM CITRATE, 99

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