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| | METHYL 3-METHOXY-4-METHYLBENZOATE Basic information | | Preparation |
| | METHYL 3-METHOXY-4-METHYLBENZOATE Chemical Properties |
| Melting point | 50-54 °C (lit.) | | Boiling point | 119-120°C 1mm | | density | 1.075±0.06 g/cm3(Predicted) | | refractive index | 1.5295 | | Fp | >230 °F | | form | powder to crystal | | color | White to Almost white | | BRN | 1948339 | | CAS DataBase Reference | 3556-83-0(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 1 | | HS Code | 29189900 |
| | METHYL 3-METHOXY-4-METHYLBENZOATE Usage And Synthesis |
| Preparation | Methyl 3-methoxy-4-methylbenzoate is synthesized by the following steps:A mixture of methyl 3-hydroxy-4-methylbenzoate 36 (25 g, 0.151 mol), Me2SO4 (28.3 ml, 0.386 mol), anhydrous K2CO3 (103.5 g, 0.75 mol) was refluxed in acetone for 2 hours. K2CO3 was filtered off, washed thoroughly with acetone. The filtrates were combined and concentrated, the residue was redissolved in EtOAc washed with water, dried (anhydrous Na2SO4), filtered and concentrated in vacuo to furnish a white solid (19.52 g). Yield : 72%. | | Chemical Properties | White low melting solid | | Uses | Methyl 3-Methoxy-4-methylbenzoate has been used as a reactant in the preparation of an antimalaria drug that consists of the 4-aminoquinoline pharmacophore of chloroquine with clotrimazole-based antimalarials. | | Synthesis Reference(s) | Journal of Medicinal Chemistry, 33, p. 1771, 1990 DOI: 10.1021/jm00168a036 | | General Description | Methyl 3-methoxy-4-methylbenzoate can be prepared by reacting diazomethane with 3-methoxy-4-methylbenzoic acid in ether. |
| | METHYL 3-METHOXY-4-METHYLBENZOATE Preparation Products And Raw materials |
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