ChemicalBook Product Catalog Organic Chemistry Carboxylic acids and derivatives Carboxylic acid halides 2-PYRAZINECARBONYL CHLORIDE

2-PYRAZINECARBONYL CHLORIDE

2-PYRAZINECARBONYL CHLORIDE Basic information
Product Name:2-PYRAZINECARBONYL CHLORIDE
Synonyms:PYRAZINE-2-CARBONYL CHLORIDE;PYRAZINE-2-CARBOXYLIC ACID CHLORIDE;TIMTEC-BB SBB010290;ASINEX-REAG BAS 07703829;2-PYRAZINECARBONYL CHLORIDE;pyrazinecarbonyl chloride;2-PYRAZINECARBONYL CHLORIDE: TECH.;Pyrazine-2-carbonyl chloride, 90+%
CAS:19847-10-0
MF:C5H3ClN2O
MW:142.54
EINECS:243-367-4
Product Categories:pharmacetical;Pyridines
Mol File:19847-10-0.mol
2-PYRAZINECARBONYL CHLORIDE Structure
2-PYRAZINECARBONYL CHLORIDE Chemical Properties
Melting point 41°C
Boiling point 214.5±20.0 °C(Predicted)
density 1.393±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka-2.50±0.10(Predicted)
Water Solubility Reacts with water.
Sensitive Moisture Sensitive
CAS DataBase Reference19847-10-0(CAS DataBase Reference)
Safety Information
Risk Statements 34
Safety Statements 26-36/37/39-45
RIDADR 3265
HazardClass 8
PackingGroup II
HS Code 2933998090
MSDS Information
ProviderLanguage
ALFA English
2-PYRAZINECARBONYL CHLORIDE Usage And Synthesis
Uses2-Pyrazinecarbonyl Chloride is an intermediate used in the synthesis of (S)-N-[1-(3-Hydroxy-3-methylbutanamido)-1-oxo-3-phenylpropan-2yl]pyrazine-2-carboxamide (H805105), which is an impurity of bortezomib (B675700), which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.
2-PYRAZINECARBONYL CHLORIDE Preparation Products And Raw materials
Raw materialsThionyl chloride-->Benzene-->Sulfuryl chloride-->2-Pyrazinecarboxylic acid
Preparation Products(S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID
Azithromycin PYRIDINE-4-SULFONYL CHLORIDE PYRIDINE-2-SULFONYL CHLORIDE Pyrazinecarbonyl chloride, 5-chloro- (9CI) Pyrazine 2-QUINOXALINECARBONYL CHLORIDE pyrazinecarbonyl chloride monohydrochloride Pyrazinecarbonyl chloride, 6-chloro- (9CI) Pyrazine-2-carbonyl chloride hydrochloride Pyrazinecarbonyl chloride, 5-ethoxy- (9CI) Pyrazinecarbonyl chloride, 5-methyl- (9CI) Pyrazinecarbonyl chloride, 3-chloro- (9CI) 2-PYRAZINECARBONYL CHLORIDE
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