Benzyl nicotinate

Benzyl nicotinate Basic information
Product Name:Benzyl nicotinate
Synonyms:3-Pyridinecarboxylic acid, phenylmethyl ester;3-Pyridinecarboxylicacid,phenylmethylester;Benzyl pyridine-3-carboxylate;benzylpyridine-3-carboxylate;Estru benzylowego kwasu nikotynowego;estrubenzylowegokwasunikotynowego;Niacin benzyl ester;niacinbenzylester
CAS:94-44-0
MF:C13H11NO2
MW:213.23
EINECS:202-332-3
Product Categories:
Mol File:94-44-0.mol
Benzyl nicotinate Structure
Benzyl nicotinate Chemical Properties
Melting point 24 °C (lit.)
Boiling point 177 °C/8 mmHg (lit.)
density 1,1165 g/cm3
refractive index n20/D 1.570
Fp 170°C
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Sparingly), Methanol (Slightly)
pka3.16±0.10(Predicted)
form neat
color Colourless to Light Beige
Merck 14,6526
BRN 159169
LogP2.400
CAS DataBase Reference94-44-0(CAS DataBase Reference)
NIST Chemistry ReferenceNicotinic acid, benzyl ester(94-44-0)
EPA Substance Registry System3-Pyridinecarboxylic acid, phenylmethyl ester (94-44-0)
Safety Information
Hazard Codes Xi
Risk Statements 36/38
Safety Statements 26
WGK Germany 2
RTECS QT0850000
8
TSCA Yes
HS Code 2933399990
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
Benzyl nicotinate Usage And Synthesis
Chemical PropertiesBenzyl nicotinate is a benzyl ester resulting from the formal condensation of the carboxy group of nicotinic acid with benzyl alcohol. It derives from a nicotinic acid. It is a vasodilator agent and is also generally used in cosmetics and drugs.It has been used as a rubefacient.
Benzyl nicotinate can be used for the synthesis of benzylpalladium complexes to be used as catalysts for the substitution of olefins with benzylic groups.
Usesbenzyl nicotinate can increase skin oxygenation—thanks to vasodilatation properties—and help stimulate the healing process of wounded skin. It is an ester form of niacin (vitamin B), benzyl alcohol, and nicotinic acid.
UsesBenzyl nicotinate can be used for the synthesis of benzylpalladium complexes to be used as catalysts for the substitution of olefins with benzylic groups.
UsesThese Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
DefinitionChEBI: A benzyl ester resulting from the formal condensation of the carboxy group of nicotinic acid with benzyl alcohol. It has been used as a rubefacient.
Synthesis Reference(s)Synthetic Communications, 14, p. 515, 1984 DOI: 10.1080/00397918408059573
General DescriptionPharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Benzyl Nicotinate is a medication widely used as a vasodilator, that widens blood vessels. It basically oxygenates and flushes the skin′s capillaries.
Clinical UseBenzyl nicotinate is used in combination with heparin in the treatment of inflammation of vein (thrombophlebitis), pain in dilated veins area, pains and cramps in the leg muscles, disturbances of lymph circulation, traffic and sports related injuries, postoperative and posttraumatic scars, non-joint rheumatism or soft tissue rheumatism.
Benzyl nicotinate Preparation Products And Raw materials
Raw materials3-Pyridinecarboxamide, N-(phenylmethoxy)--->Benzyl alcohol
Benzoyl peroxide Benzyl chloride MANNITOLNICOTINATE BENZYL 6-HYDROXYNICOTINATE Benzyl alcohol 5-Bromo-nicotinic acid 2-bromo-benzyl ester Inositol nicotinate Vitamin E nicotinate Benzyl formate Benzyl chloroformate Benzyl BENZYL 6-CHLORONICOTINATE Benzyl acetate VITAMIN E NICOTINATE Pyridine Benzyl benzoate RESMETHRIN Benzyl nicotinate

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