| | 2,4-Dinitrochlorobenzene Basic information |
| | 2,4-Dinitrochlorobenzene Chemical Properties |
| Melting point | 48-50 °C(lit.) | | Boiling point | 315 °C(lit.) | | density | 314 | | vapor density | 6.98 (vs air) | | vapor pressure | 1 hPa (106 °C) | | refractive index | 1.5857 | | Fp | 367 °F | | storage temp. | Store below +30°C. | | solubility | alcohol: very slightly soluble (cold)(lit.) | | form | Crystalline Mass, Chunks or Crystals and Powder | | color | Yellow to brown | | Odor | Almond-like | | explosive limit | 1.9-22%(V) | | Water Solubility | insoluble | | Merck | 14,2136 | | BRN | 613161 | | Stability: | Stable. Combustible. Incompatible with strong oxidizing agents, ammonia. Reacts violently with hydrazine hydrate. | | LogP | 2.24 at 23.3℃ and pH3.5-5.5 | | CAS DataBase Reference | 97-00-7(CAS DataBase Reference) | | NIST Chemistry Reference | Benzene, 1-chloro-2,4-dinitro-(97-00-7) | | EPA Substance Registry System | 2,4-Dinitrochlorobenzene (97-00-7) |
| | 2,4-Dinitrochlorobenzene Usage And Synthesis |
| Chemical Properties | yellow crystals with an almond odour | | Uses | 1-Chloro-2,4-dinitrobenzene is a benzene derivative and is used in biochemical research as a substrate for glutathione S-transferase. | | Uses | 1-Chloro-2,4-dinitrobenzene is used as a reagent for the detection and determination of pyridine compounds. It has been used as alkylating agent to evaluate the depletion of intracellular erythrocyte glutathione (GSH). It is an irreversible inhibitor of human thioredoxin reductase. | | Definition | ChEBI: 2,4-Dinitrochlorobenzene is a C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions. It has a role as an epitope, an allergen and a sensitiser. It is a C-nitro compound and a member of monochlorobenzenes. | | General Description | Pale yellow needles, almond odor. | | Reactivity Profile | Self-reactive, [Halpern, Chem. and Eng. News, 29:2666(1951)]. The mixture of 2,4-Dinitrochlorobenzene with hydrazine hydrate caused a violent reaction. | | Hazard | Toxic by ingestion, inhalation, and skin
absorption. Combustible. Upper explosive limit
22%. A skin irritant. | | Health Hazard | TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | | Fire Hazard | Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. | | Contact allergens | This substance is one of the strongest primary skin irritants known, and a universal contact allergen. Occupational dermatitis has been reported, but current use is decreasing or performed with completely closed systems. DNCB is sometimes used for topical treatment of alopecia areata, severe warts, and cutaneous metastasis of malignant melanoma | | Safety Profile | Poison by skin contact
and intraperitoneal routes. Moderately toxic
by ingestion. A severe human skin and eye
irritant. Acts as a primary irritant as well as a
sensitizer of skin. An allergen. Mutation data
reported. Combustible when exposed to
heat or flame. A moderate explosion hazard
when exposed to flame, sparks, heated to
1 50°, or when shocked in a sealed container.
Explosive reaction with ammonia at
17O℃/40 bar. To fight fire, use CO2, dry
chemical. Reacts violently with hydrazine
sulfate or hydrazine hydrate. See also
NITRO COMPOUNDS of AROMATIC
HYDROCARBONS. | | Purification Methods | Usually it is recrystallised from EtOH or MeOH. It has also been crystallised from Et2O, *C6H6, *C6H6/pet ether or isopropyl alcohol. A preliminary purification step is to pass its solution in *benzene through an alumina column. It has also been purified by zone refining. It exists in three forms: one stable and two unstable. The stable form crystallises as yellow needles from Et2O, m 51o, b 315o/760mm with some decomposition, and is soluble in EtOH. A labile form also crystallises from Et2O, m 43o, and is more soluble in organic solvents. The second labile form has m 27o. [Hoffman & Dame, J Am Chem Soc 41 1015 1919, Welsh J Am Chem Soc 63 3276 1941, J Chem Soc 2476 1957, Beilstein 5 IV 744.] |
| | 2,4-Dinitrochlorobenzene Preparation Products And Raw materials |
|
