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| | Protopine Basic information |
| Product Name: | Protopine | | Synonyms: | 7,13a-Secoberbin-13a-one, 7-methyl-2,3:9,10-bis(methylenedioxy)-;7-Methyl-6,8,9,16-tetrahydrodi[1,3]benzodioxolo[4,5-c:5,6-g]azecin-15(7H)-one;Biflorine;Bis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-13(5H)-one, 4,6,7,14-tetrahydro-5-methyl-;Corydinine;Hypercorine;Protopin;BIFLORIN | | CAS: | 130-86-9 | | MF: | C20H19NO5 | | MW: | 353.37 | | EINECS: | 204-999-6 | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 130-86-9.mol |  |
| | Protopine Chemical Properties |
| Melting point | 203-205?C | | Boiling point | 486.8°C (rough estimate) | | density | 1.399 (calc) | | refractive index | 1.5800 (estimate) | | storage temp. | Inert atmosphere,2-8°C | | Water Solubility | Insoluble in water | | solubility | DMSO : 12.5 mg/mL (35.37 mM; Need ultrasonic) | | form | powder to crystal | | pka | 7.86±0.20(Predicted) | | color | White to Light gray to Light yellow | | LogP | 3.760 (est) | | NIST Chemistry Reference | Protopine(130-86-9) |
| Safety Statements | 24/25 | | RIDADR | 1544 | | RTECS | VS2800000 | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 29391900 | | Hazardous Substances Data | 130-86-9(Hazardous Substances Data) | | Toxicity | guinea pig,LD50,intraperitoneal,116mg/kg (116mg/kg),Therapie. Vol. 28, Pg. 767, 1973. |
| | Protopine Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Uses | Protopine is a Ca2+ channel blocker and antiplatelet agent. Immunomodulator | | Definition | ChEBI: A dibenzazecine alkaloid isolated from Fumaria vaillantii. | | General Description | This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG | | Purification Methods | It crystallises from EtOH/CHCl3. The picrate has m ~240o(dec). [Beilstein 27 H 558, 17 I 568, 17 II 620, 17 III/IV 6881.] |
| | Protopine Preparation Products And Raw materials |
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