ChemicalBook Product Catalog Organic Chemistry Amides Acyclic polyamines and their derivatives (R)-2-Methyl-pyrrolidine

(R)-2-Methyl-pyrrolidine

(R)-2-Methyl-pyrrolidine Basic information
Product Name:(R)-2-Methyl-pyrrolidine
Synonyms:METHYLPYRROLIDINE(S-2-);D-2-METHYLPYRROLIDINE;(R)-2-METHYL-PYRROLIDINE;(2R)-2-Methylpyrrolidine;(2R)-2-Methylpyrrolidinehydrochloride;(2R)-2-Methylpyrrolidine hcl;C-3166R;2-(R)-Methylpyrrolidine
CAS:41720-98-3
MF:C5H11N
MW:85.15
EINECS:
Product Categories:Heterocyclic Building Blocks;Pyrrolidines;Heterocyclic Series;Benzenes;Chiral Compound;Chiral Building Blocks
Mol File:41720-98-3.mol
(R)-2-Methyl-pyrrolidine Structure
(R)-2-Methyl-pyrrolidine Chemical Properties
Boiling point 94 °C(Press: 728 Torr)
density 0.842
refractive index 1.4353
Fp 45 ºF
storage temp. 2-8°C
pka10.93±0.10(Predicted)
form oil
color Colourless to pale yellow
Water Solubility Insoluble in water.
CAS DataBase Reference41720-98-3(CAS DataBase Reference)
Safety Information
Hazard Codes C,F
Risk Statements 11-22-34
Safety Statements 26-36/37/39-45
RIDADR UN 2924
WGK Germany 3
Hazard Note Corrosive/Highly Flammable
HazardClass 3
PackingGroup Ⅱ
HS Code 29339900
MSDS Information
(R)-2-Methyl-pyrrolidine Usage And Synthesis
UsesIt is used as a building block used in a multikilogram synthesis of a chiral naphthalenoid histamine receptor antagonist.
DefinitionChEBI: (R)-2-methylpyrrolidine is a 2-methylpyrrolidine that has (R)-configuration. It is a conjugate base of a (R)-2-methylpyrrolidinium.
Application(R)-2-Methyl-pyrrolidine, an optically active amine that can be used as a key building block to synthesize:
4,5-fused pyridazinone derivatives are applicable as potent histamine H3 receptor antagonists.
Naphthalenoid histamine H3 receptor antagonist.
Pyrrolo[2,3-d]pyrimidine derivatives as potent inhibitors of leucine-rich repeat kinase 2.
ReferencesSynthesis and structure-activity relationships of 4,5-fused pyridazinones as histamine H3 receptor antagonists. DOI:10.1016/j.bmcl.2011.08.045
Efficient and Practical Synthesis of (R)-2-Methylpyrrolidine DOI:10.1021/jo060319n
Synthesis of (R)-2-Methylpyrrolidine
(R)-2-Methyl-pyrrolidine Preparation Products And Raw materials
Raw materials2-METHYL-1H-PYRROLE-->Sodium triacetoxyborohydride-->(R)-(+)-1-Phenylethanol-->L-(+)-Prolinol
Methyl Z-L-PROLINE N-Methyl-2-pyrrolidone Bensulfuron methyl N,N-Dimethylformamide Tiglic aldehyde 2,6-Dimethylphenol Poly(dimethylsiloxane) 3-Carboxy-2,2,5,5-tetraMethylpyrrolidine 1-Oxyl Free Radical METHYL-2-PYRROLIDONE Kresoxim-methyl Thiophanate-methyl L-(+)-Prolinol 3-CARBAMOYL-PROXYL Methyl acrylate Actinomycin D 2-Pyrrolidinecarboxamide,(S)- Methyl bromide
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