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| | Clinofibrate Basic information |
| Product Name: | Clinofibrate | | Synonyms: | CLINOFIBRATE (S-8527);2,2’-cyclohexane-1,1-diylbis(p-phenyleneoxy)bis(2-methylbutyricacid);lipoclin;2,2'-(cyclohexylidenebis(4,1-phenyleneoxy))bis(2-methyl)-butanoic acid;CLINOFIBRATE;CLINOFIBRATE(FORR&DONLY);1,1-Bis[4'-(1''-carboxy-1''-methylpropoxy)phenyl]cyclohexane;Butanoic acid, 2,2'-[cyclohexylidenebis(4,1-phenyleneoxy)]bis[2-methyl- | | CAS: | 30299-08-2 | | MF: | C28H36O6 | | MW: | 468.58 | | EINECS: | 1312995-182-4 | | Product Categories: | API;Inhibitors;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 30299-08-2.mol |  |
| | Clinofibrate Chemical Properties |
| Melting point | 143-145°C | | Boiling point | 498.6°C (rough estimate) | | density | 1.1005 (rough estimate) | | refractive index | 1.4482 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Sligthly) | | form | Solid | | pka | 3.00±0.10(Predicted) | | color | White to Off-White | | Merck | 14,2357 | | CAS DataBase Reference | 30299-08-2(CAS DataBase Reference) |
| RTECS | ES8900000 | | HS Code | 2918.99.4700 |
| | Clinofibrate Usage And Synthesis |
| Chemical Properties | White Solid | | Originator | Lipocrin,Sumitomo,Japan,1981 | | Uses | Clinofibrate is an antilipemic, used as an anti-atherosclerosis agent.
| | Definition | ChEBI: Clinofibrate is an organic molecular entity. | | Manufacturing Process | Into a mixture of 6.0 g of a bishydroxyphenyl derivative, and 44.0 g of methyl
ethyl ketone was added 16.2 g of crushed potassium hydroxide or sodium
hydroxide. Chloroform was added dropwise into the above mixture with
stirring at 20°C to 80°C, and the resultant mixture was heated for 20 hours
under reflux to complete the reaction. Thereafter the reaction mixture was
concentrated to give a residue. Into the residue was added water. After
cooling, the resultant mixture was treated with activated charcoal and
acidified by diluted hydrochloric acid or sulfuric acid to give an oily substance.
The oily substance was extracted by ether and the ether solution was
contacted with aqueous diluted Na2CO3 solution. The separated aqueous layer
was washed with ether, acidified and again extracted with ether. The obtained
ester layer was dried over anhydrous sodium sulfate and concentrated to give
1.0 g of a crude product which was purified by recrystallization or
chromatography, to give crystals MP 143°C to 146°C (decomp.) | | Therapeutic Function | Antihyperlipoproteinemic |
| | Clinofibrate Preparation Products And Raw materials |
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