ChemicalBook Product Catalog Chemical Reagents Organic reagents Cyanide / nitrile 2-Cyanophenol

2-Cyanophenol

2-Cyanophenol Basic information
Product Name:2-Cyanophenol
Synonyms:2-Hydroxybenzonitrile, 97+%;2-Cyanophenol SynonyMs: 2-Hydroxybenzonitrile;O-hydroxybanzo nitrile;O-HYDROXYBENZONITRILE;SALICYLIC ACID NITRILE;SALICYLONITRILE;2-CYANOPHENOL (2-HYDROXYBENZONITRILE);O-HYDROXYBENZONITRIL
CAS:611-20-1
MF:C7H5NO
MW:119.12
EINECS:210-259-3
Product Categories:Miscellaneous;Imidazoles ,Homopiperidines;Aromatic Nitriles
Mol File:611-20-1.mol
2-Cyanophenol Structure
2-Cyanophenol Chemical Properties
Melting point 92-95 °C (lit.)
Boiling point 149 °C/14 mmHg (lit.)
density 1.1052
vapor pressure 0.17Pa at 25℃
refractive index 1.5372
Fp 149°C/14mm
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Sparingly), Methanol (Slightly)
form Crystalline Powder
pka6.86(at 25℃)
color Off-white to brown
Water Solubility soluble
BRN 1210029
Stability:Stable. Incompatible with strong oxidizing agents, strong bases.
LogP1.66 at 30℃
CAS DataBase Reference611-20-1(CAS DataBase Reference)
NIST Chemistry ReferenceBenzonitrile, 2-hydroxy-(611-20-1)
EPA Substance Registry SystemBenzonitrile, 2-hydroxy- (611-20-1)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38-20/21/22
Safety Statements 26-36-45
WGK Germany 3
Hazard Note Irritant
TSCA Yes
HS Code 29269095
MSDS Information
ProviderLanguage
2-Cyanophenol English
SigmaAldrich English
ACROS English
ALFA English
2-Cyanophenol Usage And Synthesis
Chemical Properties2-Cyanophenol is a white to light yellow crystal powder with a pungent and bitter odor. It is partially soluble in water with a Pka value of 7.17. However, it is unstable when exposed to strong alkalis and oxidants. It is an important intermediate for the synthesis of the fungicide azoxystrobin and the antihypertensive drug Bunirolol.
Uses2-Hydroxybenzonitrile is used as starting reagent during the synthesis of mono-alkoxyphenyloxazoline, furanoside.
PreparationA method for preparing 2-cyanophenol, which comprises the following steps: preparing salicylaldoxime; performing dehydration; and performing hydrolytic-acidification reaction, wherein in the dehydration, anhydride is adopted as a dehydrating agent; and in the hydrolytic-acidification reaction, a hydrolyticreagent is 10 to 30 mass percent alkaline solution, and the temperature of the hydrolytic-acidification reaction is 100 to 150℃.
DefinitionChEBI: 2-Cyanophenol is a member of benzenes and a nitrile.
Application2-Cyanophenol is used in the synthesis of CDK/GSK-3 inhibitors, for usage as therapeutics in Alzheimer's disease (AD).
Flammability and ExplosibilityNotclassified
Synthesis2-Hydroxybenzonitrile can be synthesized by condensing salicylaldehyde with hydroxylamine hydrochloride to produce salicylaldoxime. Then, the salicylaldoxime is reacted with acetic anhydride followed by hydrolysis to yield 2-Hydroxybenzonitrile.
Process for the preparation of 2-hydroxybenzonitrile
storageStore at 2°C - 8°C, close container well, protect from light.                                   
2-CHLORO-6-METHOXYBENZONITRILE 2-chloro-6-benzyloxybenzonitrile 4-CYANOPHENOL 95% 4-Cyanophenol anion 4-Chloro-2-cyanophenol 2,6-Difluoro-4-Cyanophenol Hydroxy silicone oil 5-Bromo-2-cyanophenol 2-METHOXY-1-NAPHTHONITRILE 2,6-DIHYDROXY-3-NITROBENZONITRILE 4-HYDROXYBENZONITRILE, (4-CYANOPHENOL) 2-ACETYL-4-CYANOPHENOL 4-CYANOPHENOL-2,3,5,6-D4 4-CYANOPHENOL, [CYANO-14C] ORTHO-CYANOPHENOL 2-HYDROXYBENZONITRILE, (2-CYANOPHENOL) 2-methoxy-5-nitrobenzonitrile 3,6-Dihydroxyphthalonitrile Cyanophenol
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