Camphene

Camphene Basic information
Product Name:Camphene
Synonyms:Camphene(DOT);2,2-Dimethyl-3-methylene-bicyclo[2.2.1]heptane;(n)-camphene;Camphene, 75%, remainder mainly alpha-fenchene;DL-CAMPHENE, TECH;2-Dimethyl-3-methylenenorbornane;CaMphene, reMainder Mainly alpha-fenchene, 75% 1LT;CAMPHENE WITH GC
CAS:79-92-5
MF:C10H16
MW:136.23
EINECS:201-234-8
Product Categories:Pharmaceutical Intermediates;Bicyclic Monoterpenes;Biochemistry;Terpenes;Alpha Sort;C;CA - CG;CAlphabetic;Volatiles/ Semivolatiles;Acyclic;Alkenes;Organic Building Blocks
Mol File:79-92-5.mol
Camphene Structure
Camphene Chemical Properties
Melting point 48-52 °C (lit.)
Boiling point 159-160 °C (lit.)
density 0.85 g/mL at 25 °C (lit.)
vapor pressure 3.99 hPa (20 °C)
refractive index 1.4551
FEMA 2229 | CAMPHENE
Fp 94 °F
storage temp. 2-8°C
solubility 0.0042g/l
form Crystalline Low Melting Solid
color White
Specific Gravity0.85
PH5.5 (H2O, 22℃)(saturated aqueous solution)
Odorat 10.00 % in dipropylene glycol. woody herbal fir needle camphor terpenic
Odor Threshold0.88ppm
Odor Typewoody
Water Solubility practically insoluble
Merck 14,1730
JECFA Number1323
InChIKeyCRPUJAZIXJMDBK-DTWKUNHWSA-N
LogP4.22 at 20℃
CAS DataBase Reference79-92-5(CAS DataBase Reference)
NIST Chemistry ReferenceCamphene(79-92-5)
EPA Substance Registry SystemCamphene (79-92-5)
Safety Information
Hazard Codes F,N
Risk Statements 11-10-50/53-36
Safety Statements 16-33-61-60-26
RIDADR UN 1325 4.1/PG 2
WGK Germany 2
RTECS EX1055000
Autoignition Temperature265 °C
HS Code 2902 19 00
HazardClass 4.1
PackingGroup III
Hazardous Substances Data79-92-5(Hazardous Substances Data)
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
Camphene Usage And Synthesis
Chemical PropertiesWHITE CRYSTALLINE LOW MELTING SOLID
Chemical PropertiesCamphene is a colorless to white crystalline solid, Camphor, or turpentine odor. It may be shipped as a liquid. Freezing/Melting point 5 50C.
Chemical PropertiesCamphene has a terpene, camphoraceous taste.
OccurrenceReported found in carrot, dill, fennel, marjoram, nutmeg, parsley, pepper, tarragon and thyme.
UsesCamphene is used in the preparation of fragrances and as a food additive for flavoring.
UsesManufacture of synthetic camphor, camphor substitute.
DefinitionChEBI: A monoterpene with a bicyclic skeleton that is bicyclo[2.2.1]heptane substituted by geminal methyl groups at position 2 and a methylidene group at position 3. It is a widespread natural product found in many essential oils.
PreparationFrom pinene by catalytic isomerization or from bornyl chloride by heating with alkali in the presence of abietenesulfonic acid.
Aroma threshold valuesDetection at 10%: camphoraceous, cooling, piney woody with terphy nuances. It has citrus and green minty and green spicy notes.
Taste threshold valuesTaste characteristics at 50–100 ppm: camphoraceous, cooling, minty, with citrus and green spicy nuances.
General DescriptionA colorless to white crystalline solid with an insipid camphor-like odor. Dust and crystals are irritants to the eyes, nose and throat. Emits flammable vapors when heated. Emits acrid smoke and irritating fumes at high temperature. Used for the manufacture of synthetic camphor.
Reactivity ProfileCamphene may react vigorously with strong oxidizing agents. May react exothermically with reducing agents to release hydrogen gas.
HazardToxic by ingestion.
Health HazardInhalation causes irritation of nose and throat. Contact with eyes or skin causes irritation.
Flammability and ExplosibilityFlammable
PharmacologyOral administration of camphene (260 mmols/kg) to rats increased bile flow by 50% 4 hr after administration (M?rsdorf, 1966). Development of atheromatosis of the aorta in rabbits fed 1 g cholesterol/day for 3 months was considerably inhibited by simultaneous administration of a mixture of terpenes including camphene, injected sc in a dose of 1 ml every other day for 6 wk and then given orally in doses of 2 ml/day (Benk?, Macher, Szarvas & Tiboldi, 1961). The effect of 1 g cholesterol/day for 8 wk in the diet of rabbits in increasing the number and volume of mast cells in the aortic adventitia and increasing the total lipid content of the aortic wall was slightly enhanced by the simultaneous addition of 11 g camphene/day (Lesznyak, Benko, Szabo & Muller, 1972). This camphene treatment also decreased the lipid accumulation in the liver, but had no effect on the cholesterol-induced atheromatosis of the aorta (Benko, Szabo, Muller & Lesznyak, 1972).
Anticancer ResearchThis was tested against melanoma cells in a syngeneic model, and there was promisingantitumor activity (Ma et al. 2016).
Safety ProfileMutation data reported. Combustible; yields flammable vapors when heated and can react with oxidizing materials. To fight fire, use water spray, foam, fog, CO2. When heated to decomposition it emits acrid smoke and irritating fumes.
Potential ExposureCamphene is used to manufacture synthetic camphor; for making moth-proofing and in the cosmetics, perfume, and food flavoring industries.
ShippingUN1325 Flammable solids, organic, n.o.s., Hazard Class: 4.1; Labels: 4.1-Flammable solid. UN2319 Terpene hydrocarbons, n.o.s., Hazard Class: 3; Labels: 3- Flammable liquid
IncompatibilitiesForms explosive mixture with air. Emulsions in xylene may violently decompose on contact with iron or aluminum above 70C. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Contact with reducing agents may cause exothermic reaction, releasing flammable hydrogen gas
Waste DisposalDissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
Camphene Preparation Products And Raw materials
Raw materialsTurpentine oil-->Metatitanic acid-->Rutile-->ALPHA-PINENE-->alpha-Pinene-->GAMMA-TERPINENE-->DL-Limonene-->Acetic acid
Preparation ProductsTerpinyl cyclohexanol mixture-->2-Bornene-->Terpinolene
Methylene Chloride Heptane 2,2-Dimethyl-5-methylenenorbornane Methylene Blue (+/-)-10-CAMPHORSULFONIC ACID SODIUM SALT ETHANE Camphene (contains ca 20% trycyclene),CAMPHENE(RG),(+-)-CAMPHENE (CONTAINS CA 20%RICYCLENE) 80+%,D,L-CAMPHENE,CAMPHENE 90,CAMPHENE 46 Dimethyl sulfide Dimethyl fumarate Dimethyl sulfoxide 4,4'-Diphenylmethane diisocyanate N-NITROSODIMETHYLAMINE White camphor oil L-Camphen Dimethyl ether Camphene60% Camphene Dimethyl phthalate

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