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| | 2-Hydroxybenzyl alcohol Basic information |
| | 2-Hydroxybenzyl alcohol Chemical Properties |
| Melting point | 83-85 °C(lit.) | | Boiling point | 190.92°C (rough estimate) | | density | 1,613 g/cm3 | | refractive index | 1.5035 (estimate) | | storage temp. | Store below +30°C. | | solubility | ethanol: soluble5%, clear to very slightly hazy, colorless to light yellow | | pka | pK1:9.92 (25°C) | | form | Crystalline Flakes or Powder | | color | Light beige | | Water Solubility | 67 g/L (22 ºC) | | Merck | 14,8325 | | BRN | 1907195 | | Stability: | Stable. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents. | | LogP | 0.730 | | CAS DataBase Reference | 90-01-7(CAS DataBase Reference) | | NIST Chemistry Reference | Salicyl alcohol(90-01-7) | | EPA Substance Registry System | 2-Hydroxybenzenemethanol (90-01-7) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | DO6430000 | | TSCA | Yes | | HS Code | 29072900 |
| | 2-Hydroxybenzyl alcohol Usage And Synthesis |
| Chemical Properties | light brown crystalline powder | | Chemical Properties | Salicyl alcohol: (saligenin, o-hydroxy benzyl alcohol) crystallizes from water in the form of needles or white rhombic crystals. It occurs in nature as the bitter glycoside, salicin CAS: 138-52-3, which is isolated from the bark of Salix helix, S. pentandra, S. praecos, some other species of willow trees, and the bark of a number of species of poplar trees such as Polpulus balsamifera, P. candicans, and P. nigra. | | Uses | anesthetic (local), antiinflammatory | | Uses | 2-Hydroxybenzyl Alcohol is a phenolic component of a part of a salix bark extract which maintains a minor anti-depressant effect. Phenolic analog with potential for anti-melanomic effect. Also It is an intermediate in the production of phenol formaldehyde res ins (may remain after condensation of the resin); sensitizer in phenol-formaldehyde resins; in loeal anesthetics. | | Definition | ChEBI: A hydroxybenzyl alcohol that is phenol substituted by a hydroxymethyl group at C-2. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 60, p. 5314, 1995 DOI: 10.1021/jo00121a060
Tetrahedron Letters, 10, p. 1739, 1969 | | General Description | 2-Hydroxybenzyl alcohol participates in the selective ring opening reaction of 4H-1,3,2-benzodioxasilines. | | Contact allergens | Methylol phenols are sensitizers contained in resins
based on phenol and formaldehyde of the resol type.
Cross-reactivity is possible with other phenol derivative
molecules. | | Purification Methods | Crystallise saligenine from water or EtOH/*C6H6 (m 89o). [Beilstein 6 III 4537, 6 IV 5896.] |
| | 2-Hydroxybenzyl alcohol Preparation Products And Raw materials |
| Raw materials | Formaldehyde | | Preparation Products | Xanthene-->SALITHION-->2-DIMETHYLAMINOMETHYLPHENOL (CONTAINS PHENOL)-->2,2'-METHYLENEDIPHENOL-->2-SALICYLIDENEAMINOPHENOL-->5-(CHLOROMETHYL)-2-HYDROXYBENZALDEHYDE-->N,N'-DISALICYLAL-1,2-PHENYLENEDIAMINE-->SALICYLIDENEANILINE-->2,4,4,6-TETRABROMO-2,5-CYCLOHEXADIENONE-->4H-1,3-Benzodioxin, 2,2-dimethyl--->CHEMBRDG-BB 9070765-->2-(1H-IMIDAZOL-2-YLMETHYL)-PHENOL-->o-Hydroxybenzylchloride |
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