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| Product Name: | 4-Aminoacetophenone | | Synonyms: | 1-(4-aminophenyl)-ethanon;1-(4-aminophenyl)ethanone[qr];4’-amino-acetophenon;4’-aminoacetophenone[qr];Acetophenone, p-amino-;Acetophenone,4’-amino-;acetophenone,4-amino-[qr];acetophenone,p-amino-[qr] | | CAS: | 99-92-3 | | MF: | C8H9NO | | MW: | 135.16 | | EINECS: | 202-801-2 | | Product Categories: | Amines;Aromatics;99-92-3 | | Mol File: | 99-92-3.mol |  |
| | 4-Aminoacetophenone Chemical Properties |
| Melting point | 103-107 °C(lit.) | | Boiling point | 293 °C(lit.) | | density | 0,77 g/cm | | refractive index | 1.5700 (estimate) | | Fp | 292-294°C | | storage temp. | Store below +30°C. | | solubility | 6.5g/l | | pka | 2.17±0.10(Predicted) | | form | Crystalline Powder | | color | Slightly yellow to brown | | Specific Gravity | 0.77 | | Water Solubility | It is soluble in hot water, ethanol and ether. | | Merck | 14,413 | | BRN | 471493 | | InChIKey | GPRYKVSEZCQIHD-UHFFFAOYSA-N | | LogP | 0.830 | | CAS DataBase Reference | 99-92-3(CAS DataBase Reference) | | NIST Chemistry Reference | Acetophenone, 4'-amino-(99-92-3) | | EPA Substance Registry System | 4'-Aminoacetophenone (99-92-3) |
| | 4-Aminoacetophenone Usage And Synthesis |
| Description | 4-Aminoacetophenone is in the form of yellow needle-like crystals, with a melting point of 106°C, a boiling point of 293-295°C, and 195-200°C (2kPa). Soluble in hot water, soluble in alcohol, ether, dilute hydrochloric acid and dilute sulfuric acid, it is slightly soluble in benzene and cold water. Has a special pleasant fragrance. It can be used as a pharmaceutical intermediate.
 | | Synthesis | Through a Williamson ether synthesis method and Smiles rearrangement reaction, benzamide compounds are produced, then the 4-aminoacetophenone preparation is finished after hydrolysis. | | Applications | 4′-Aminoacetophenone, is used in pharmaceuticals, medicines and other organic products. It is also used as a reagent for the photometric determination of Ce. As pharmaceutical intemediate or in the determination of palladium and vitaminB1.
| | Notes | Store in cool place. Keep container tightly closed in a dry and well-ventilated place. acids, Incompatible to Acid chlorides, Acid anhydrides, Chloroformates, Strong oxidizing agents, Strong reducing agents. Stable under ordinary conditions.
| | Chemical Properties | slightly yellow to brown crystalline powder | | Uses | A novel utilization of aminophenone derivative in toxicology, for treating intoxications with cyanogenic toxic substances. | | Uses | 4'-Aminoacetophenone, is used in pharmaceuticals, medicines and other organic products. It is also used as a reagent for the photometric determination of Ce. As pharmaceutical intemediate or in the determination of palladium and vitaminB1. | | Uses | 4-Aminoacetophenone is a novel utilization of aminophenone derivative in toxicology used for treating intoxications with cyanogenic toxic substances. | | Synthesis Reference(s) | Chemical and Pharmaceutical Bulletin, 34, p. 2013, 1986 DOI: 10.1248/cpb.34.2013
Tetrahedron Letters, 27, p. 4687, 1986 DOI: 10.1016/S0040-4039(00)85038-8 | | General Description | 4′-Aminoacetophenone, commonly known as Clenbuterol Impurity D, is a related compound of sympathomimetic amine drug clenbuterol. Clenbuterol belongs to a group of compounds referred to as β-2-agonists and is generally used in the treatment of asthma.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | | Safety Profile | Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NO,. See also AROMATIC AMINES | | Purification Methods | It is soluble in hot H2O. UV (EtOH) has max 403nm (log 4.42) [Johnson J Am Chem Soc 75 2720 1953]. [Vandenbelt Anal Chem 26 726 1954.] The 2,4-dinitrophenylhydrazone has m 266-267o (from CHCl3 or EtOH) with 403nm (log 4.42), and the max semicarbazone has m 193-194o(dec)(from MeOH). The hydrochloride has m 98o(dec)(from H2O). [Beilstein 14 IV 100.] | | Toxicity evaluation | Harmful if swallowed. Causes eye, skin, and respiratory tract irritation. May cause methemoglobinemia. |
| | 4-Aminoacetophenone Preparation Products And Raw materials |
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