Poly(1-vinylpyrrolidone-co-vinyl acetate)

Poly(1-vinylpyrrolidone-co-vinyl acetate) Basic information
Product Name:Poly(1-vinylpyrrolidone-co-vinyl acetate)
Synonyms:kolima10;kolima35;kolima75;luviskolva28i;luviskolva37e;luviskolva37i;luviskolva55e;luviskolva55i
CAS:25086-89-9
MF:C10H15NO3
MW:197.23
EINECS:
Product Categories:Poly(vinylpyrrolidone);Vinylpyridine and Vinypyrrolidone Polymers;Hair Care;API;Hydrophobic Polymers;Materials Science;Polymer Science;Vinylpyridine and Vinypyrrolidone Polymers;Polymers;Hydrophobic Polymers;J's
Mol File:25086-89-9.mol
Poly(1-vinylpyrrolidone-co-vinyl acetate) Structure
Poly(1-vinylpyrrolidone-co-vinyl acetate) Chemical Properties
density 1.27 g/mL at 25 °C(lit.)
refractive index 1.4300 to 1.4380
Fp 72 °F
solubility Greater than 10% solubility in 1,4-butanediol, glycerol, butanol, chloroform, dichloromethane, ethanol (95%), glycerol, methanol, polyethylene glycol 400, propan-2-ol, propanol, propylene glycol, and water. Less than 1% solubility in cyclohexane, diethyl ether, liquid paraffin, and pentane.
form powder
color White
Stability:Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents.
InChIInChI=1S/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3
InChIKeyFYUWIEKAVLOHSE-UHFFFAOYSA-N
SMILESC(N1CCCC1=O)=C.O(C=C)C(=O)C
LogP0.370 (est)
EPA Substance Registry SystemVinyl acetate N-vinyl-pyrrolidone polymer (25086-89-9)
Safety Information
Hazard Codes Xi,F
Risk Statements 10-36/37/38-67-36-11-22
Safety Statements 22-24/25-36/37/39-26-16
RIDADR UN 1987 3/PG 2
WGK Germany 1
RTECS AH3539000
HazardClass 3
PackingGroup II
HS Code 29349990
ToxicityLD50 orl-rat: >630 mg/kg JACTDZ 2(5),141,83
MSDS Information
ProviderLanguage
SigmaAldrich English
Poly(1-vinylpyrrolidone-co-vinyl acetate) Usage And Synthesis
Chemical PropertiesCopovidone is a white to yellowish-white amorphous powder. It is typically spray-dried with a relatively fine particle size. It has a slight odor and a faint taste.
Chemical Propertieswhite powder
UsesCopovidone is a water-soluble polymer used to improve the uptake and drug loading of various pharmaceutical agents, including contraceptive patches.
UsesPoly(1-vinylpyrrolidone-co-vinyl acetate)
Production MethodsCopovidone is manufactured by free-radical polymerization of vinylpyrrolidone and vinyl acetate in a ratio of 6 : 4. The synthesis is conducted in an organic solvent owing to the insolubility of vinyl acetate in water.
General Description~1:2.4 mole ratio of VP:VA
Pharmaceutical ApplicationsCopovidone is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.
Safety ProfileModerately toxic by ingestion.Combustible, especially in powdered form. Incompatiblewith strong oxidising agents, strong reducing agents. Whenheated to decomposition it emits toxic vapors of NOx.
SafetyCopovidone is used widely in pharmaceutical formulations and is generally regarded as nontoxic. However, it is moderately toxic by ingestion, producing gastric disturbances. It has no irritating or sensitizing effects on the skin. A study was conducted to look at the carcinogenicity and chronic toxicity of copovidone (Kollidon VA 64) in Wistar rats and Beagle dogs. The results of these studies demonstrated the absence of any significant toxicological findings of high dietary levels of copodivone in rats and dogs, resulting in noobserved- adverse-effect levels of 2800 mg/kg body-weight/day in rats and 2500 mg/kg body-weight/day in dogs, the highest doses tested.
LD50 (rat, oral): >0.63 g/kg
storageCopovidone is stable and should be stored in a well-closed container in a cool, dry place.
IncompatibilitiesCopovidone is compatible with most organic and inorganic pharmaceutical ingredients. When exposed to high water levels, copovidone may form molecular adducts with some materials; see Crospovidone and Povidone.
Regulatory StatusCopovidone is included in the FDA Inactive Ingredients Database (oral tablets, oral film-coated tablets, sustained action).
Poly(1-vinylpyrrolidone-co-vinyl acetate) Preparation Products And Raw materials
Ethylene-vinyl acetate copolymer AMBERLYST(R) 15 N-Octyl pyrrolidone Polyvinylpyrrolidone cross-linked 1-Butylpyrrolidin-2-one N-OCTYL PYRROLIDINE N-ISOPROPYL-2-PYRROLIDONE 1-Propylpyrrolidin-2-one 1-(3-METHOXYPROPYL)-2-PYRROLIDINONE 3-(1-PYRROLIDINYL)-1-BUTANOL 1-(3-HYDROXYPROPYL)-2-PYRROLIDONE METHYL-2-PYRROLIDONE 1-Heptyl-2-Pyrrolidone Isopropyl acetate ACETATE 1-HEXYL-PYRROLIDIN-2-ONE 1-Pentyl-2-Pyrrolidone Poly(1-vinylpyrrolidone-co-vinyl acetate)

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