4-PHENOXYPHENYLBORONIC ACID

4-PHENOXYPHENYLBORONIC ACID Basic information

Product Name:	4-PHENOXYPHENYLBORONIC ACID
Synonyms:	4-PHENOXYBENZENEBORONIC ACID;4-PHENOXYPHENYLBORONIC ACID;AKOS BRN-0132;RARECHEM AH PB 0260;(P-PHENOXYPHENYL)BORONIC ACID;TIMTEC-BB SBB003409;4-Phenoxybenzeneboronic acid 98%;4-Phenoxyphenylboronic acid,97%
CAS:	51067-38-0
MF:	C12H11BO3
MW:	214.02
EINECS:
Product Categories:	blocks;BoronicAcids;Heterocyclic Compounds;Aryl;Organoborons;Boronic Acids;Boronic Acids and Derivatives;Boronic Acids
Mol File:	51067-38-0.mol

4-PHENOXYPHENYLBORONIC ACID Chemical Properties

Melting point	141-145 °C(lit.)
Boiling point	377.0±44.0 °C(Predicted)
density	1.23±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
form	Crystalline Powder
pka	8.76±0.10(Predicted)
color	White to beige
InChI	InChI=1S/C12H11BO3/c14-13(15)10-6-8-12(9-7-10)16-11-4-2-1-3-5-11/h1-9,14-15H
InChIKey	KFXUHRXGLWUOJT-UHFFFAOYSA-N
SMILES	B(C1=CC=C(OC2=CC=CC=C2)C=C1)(O)O
CAS DataBase Reference	51067-38-0(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	37/39-26
WGK Germany	3
HazardClass	IRRITANT
HS Code	29319090

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English

4-PHENOXYPHENYLBORONIC ACID Usage And Synthesis

Chemical Properties	white to off-white powder and chunk
Uses	suzuki reaction
Uses	4-Phenoxybenzeneboronic Acid is an intermediate used to prepare biphenyl derivatives of nitotrifluoromethoxybenzyloxydihydroimidazooxazines with antitubercular activity. It is also used in the synthesis of pyrrolo pyrimidines as potent inhibitors of Lck kinase.
Uses	4-Phenoxyphenylboronic acid can be used as a reactant: In the Suzuki-Miyaura coupling reaction to synthesize aryl derivatives via C-C bond formation by reacting with different aryl halides over a palladium catalyst. To prepare 1-phenoxy-4-(trifluoromethyl)benzene via oxidative trifluoromethylation using Chan-Lam-type reaction conditions. To synthesize evobrutinib, a potent Bruton′s tyrosine kinase (BTK) inhibitor.

4-PHENOXYPHENYLBORONIC ACID Preparation Products And Raw materials

Raw materials	Tetrahydrofuran-->n-Butyllithium-->Trimethyl borate-->4-Bromophenoxybenzene-->2-BROMODIPHENYL ETHER
Preparation Products	4-(TRIFLUOROMETHYL)DIPHENYL ETHER-->4-NITROPHENYL PHENYL ETHER-->4-Phenoxyphenol-->Benzene, 1-bromo-2-fluoro-4-phenoxy--->5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine-->1-Phenoxy-4-(2-propenyl)benzene

1-Methyl-4-pyrazole boronic acid pinacol ester 3-Tolylboronic acid 3-Carboxyphenylboronic acid 4-(Hydroxymethyl)phenylboronic acid 4-Chloro-2-fluoro-3-methoxyphenylboronic acid 3,4,5-Trifluorophenylboronic acid 4''-PROPYL-3-FLUOROBIPHENYL-4-BORONIC ACID Phenoxyphenyl-4-boronic acid pinacol ester 2-PHENOXYPHENYLBORONIC ACID SOLID VARYING AMOUNTS IN ANHYDRIDE,2-PHENOXYPHENYLBORONIC ACID 4,4'-OXYBIS(1,4-BENZENE)DIBORONIC ACID 4-PHENOXYPHENYLBORONIC ACID, PINACOL ESTER 4-(2-Nitrophenoxy)phenylboronic acid 4-(2-Aminophenoxy)phenylboronic acid, HCl 4-(4-boronophenoxy)-3-nitrobenzotrifluoride 2-FLUORO-6-PHENOXYPHENYLBORONIC ACID 3-Cyanophenylboronic acid 4-Boronophenyl 4-fluoro-2-nitrophenyl ether 4-PHENOXYPHENYLBORONIC ACID

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