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| | BIX 01294 Basic information |
| Product Name: | BIX 01294 | | Synonyms: | BIX 01294 Trihydrochloride Hydrate;4-Quinazolinamine, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-, hydrochloride (1:3);2-(Hexahydro-4-Methyl-1H-1,4-Diazepin-1-yl)-6,7-Dimethoxy-[1-(Phenylmethyl)-4-Piperidynyl]-4-Quinazolinamine Trihydrochloride BIX01294 hydrochloride;BIX01294 hydrochloride;BIX01294 3hydrochloride;Trihydrochloride Hydrate;N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine;BIX 01204 | | CAS: | 1392399-03-9 | | MF: | C28H41Cl3N6O2 | | MW: | 600.02314 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 1392399-03-9.mol |  |
| | BIX 01294 Chemical Properties |
| storage temp. | Inert atmosphere,2-8°C | | solubility | H2O: >20mg/mL | | form | powder | | color | white |
| WGK Germany | 3 | | HS Code | 2933.99.8290 |
| | BIX 01294 Usage And Synthesis |
| Uses | BIX 01294 trihydrochloride hydrate has been used:
- as a histone methylation inhibitor to treat E4 cells for analysing green fluorescent protein (d2EGFP) expression
- to investigate the role of G9a in neuroblastoma tumor growth
- as specific inhibitor of G9a to treat the SK-N-AS, BE(2)-C, SK-N-DZ, SK-N-F1, and SHEP1 neuroblastoma cell lines
| | General Description | BIX-01294, a diazepin-quinazolinamine derivative, is a histone-lysine methyltransferase (HMTase) inhibitor that modulates the epigenetic status of chromatin. BIX-01294 inhibits the G9aHMTase dependent levels of histone-3 lysine (9) methylation (H3K9me). Bix-01294 and valproic acid, a histone deacetylase (HDAC) inhibitor, may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes. | | Biochem/physiol Actions | BIX 01294 is a selective histone methyl transferase inhibitor. In its inhibition of the histone lysine methyltransferases, BIX 01294 does not compete with cofactor S-adenosyl-methionine. The target enzyme is G9a, and it selectively impairs G9a HMTase and the generation of H3K9me2 in vitro. | | storage | room temperature (desiccate) |
| | BIX 01294 Preparation Products And Raw materials |
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