ChemicalBook Product Catalog Organic Chemistry Carboxylic acids and derivatives (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Basic information
Product Name:(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
Synonyms:(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester;BIBF1120 Intermediate4;Nintedanib ethanesulfonate intermediates;(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl este;methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate;1H-Indole-6-carboxylic acid, 2,3-dihydro-3-(methoxyphenylmethylene)-2-oxo-, methyl ester, (3E)-;Nintedanib Intermediate 4;(3E)-2
CAS:1168150-46-6
MF:C18H15NO4
MW:309.32
EINECS:927-895-9
Product Categories:
Mol File:1168150-46-6.mol
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Structure
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Chemical Properties
Boiling point 523.8±50.0 °C(Predicted)
density 1.273±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka10.62±0.20(Predicted)
form Solid
color Light Yellow
Safety Information
MSDS Information
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Usage And Synthesis
Uses(E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate is an intermediate of (E)-Intedanib [I666670]. It is also used as a reactant in the preparation of deuterated derivatives of Nintedanib (N478290), which is angiokinase inhibitor with antitumor activity.
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Preparation Products And Raw materials
Nintedanib Ethanesulfonate Salt 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate 1-Chloro-4-(trimethoxymethyl)benzene N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide Avibactam INT 1 (Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate N-Methyl-4-nitroaniline N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 2-broMo-N-Methyl-N-(4-nitrophenyl)acetaMide Methyl 2-oxoindole-6-carboxylate 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE Nintedanib NXL 104 N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide Methyl 1-acetyl-2-oxoindoline-6-carboxylate BIBF-1120
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