Carbonic Anhydrase IX/XII Inhibitor II(U-104)

Carbonic Anhydrase IX/XII Inhibitor II(U-104) Basic information
Product Name:Carbonic Anhydrase IX/XII Inhibitor II(U-104)
Synonyms:NSC 213841;Carbonic Anhydrase IX/XII Inhibitor II(U-104);U-104;MST-104 ;4-[[[(4-Fluorophenyl)amino]carbonyl]amino]benzenesulfonamide;CS-1653;arbonic Anhydrase IX/XII Inhibitor II(U-104);NSC-213841; MST-104;U104;U 104
CAS:178606-66-1
MF:C13H12FN3O3S
MW:309.32
EINECS:
Product Categories:Inhibitors;Inhibitor
Mol File:178606-66-1.mol
Carbonic Anhydrase IX/XII Inhibitor II(U-104) Structure
Carbonic Anhydrase IX/XII Inhibitor II(U-104) Chemical Properties
Melting point 242-243℃
density 1.523±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 2-8°C
solubility DMSO: >15mg/mL
form powder
pka9.94±0.12(Predicted)
color white to beige
Safety Information
Hazard Codes Xi
Risk Statements 36
Safety Statements 26
WGK Germany 3
MSDS Information
Carbonic Anhydrase IX/XII Inhibitor II(U-104) Usage And Synthesis
UsesU 104 targets hypoxia-induced carbonic anhydrase IX, which inhibits tumor growth and metastasis.
Biological Activityu-104 is a novel ureido-sulfonamide inhibitor of carbonic anhydrase ix (caix). tumor volume measurements show important inhibition of primary tumor growth in the mice treated with the u-104 compound compared with vehicle controls. it also has ability to inhibit metastasis formation in the 4t1 experimental metastasis model.yuanmei lou, paul c. mcdonald, arusha oloumi, stephen chia, christina ostlund, ardalan ahmadi, alastair kyle, ulrich auf dem keller, samuel leung, david huntsman, blaise clarke, brent w. sutherland, dawn waterhouse, marcel bally, calvin roskelley, christopher m. overall, andrew minchinton, fabio pacchiano, fabrizio carta, andrea scozzafava, nadia touisni, jean-yves winum, claudiu t. supuran, shoukat dedhar. targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase ix inhibitors. cancer research may 1, 2011 71; 3364
Biochem/physiol ActionsU-104 is an inhibitor of CA IX that binds only to CA IX under hypoxic conditions in vivo. The binding results in significant inhibition of tumor growth and metastasis formation in both spontaneous and experimental models of metastasis. U-104 reduces the medium acidity by inhibiting the catalytic activity of the CA IX. It binds specifically only to hypoxic cells expressing CA IX.
Carbonic Anhydrase IX/XII Inhibitor II(U-104) Preparation Products And Raw materials
Raw materials4-Fluorophenyl isocyanate-->Sulfanilamide
Crenolanib (CP-868596) (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Erlotinib hydrochloride Tozasertib Gefitinib AZD-4547

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.