Ethyl malonyl chloride

Ethyl malonyl chloride Basic information
Product Name:Ethyl malonyl chloride
Synonyms:Acetic acid, (chloroformyl)-, ethyl ester;Carbethoxyethanoyl chloride;Ethyl 3-oxo-3-chloropropanoate;Ethyl malonyl chloride, 90%, tech.;3-Oxo-3-chloropropanoic acid ethyl ester;3-Oxo-3-chloropropionic acid ethyl ester;2-(chlorocarbonyl)butanoic acid;Ethyl malonyl chloride,Ethyl (chloroformyl)acetate, Ethyl 3-chloro-3-oxopropionate
CAS:36239-09-5
MF:C5H7ClO3
MW:150.56
EINECS:252-934-5
Product Categories:Acid Halides;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Pharmaceutical raw material;Aliphatics;Pharmaceutical intermdiate
Mol File:36239-09-5.mol
Ethyl malonyl chloride Structure
Ethyl malonyl chloride Chemical Properties
Boiling point 79-80 °C25 mm Hg(lit.)
density 1.196 g/mL at 20 °C
refractive index n20/D 1.429(lit.)
Fp 154 °F
storage temp. 2-8°C
solubility Chloroform (Soluble), DMSO (Sparingly), Ethyl Acetate (Slightly)
pka9.35±0.46(Predicted)
form Liquid
color Clear yellow to brown
Specific Gravity1.176
Water Solubility REACTS
Sensitive Moisture Sensitive
BRN 636215
Stability:Hygroscopic, Moisture Sensitive
CAS DataBase Reference36239-09-5(CAS DataBase Reference)
NIST Chemistry ReferenceEthyl malonyl chloride(36239-09-5)
Safety Information
Hazard Codes C
Risk Statements 14-34
Safety Statements 7-26-36/37/39-45-36/39
RIDADR UN 3265 8/PG 3
WGK Germany 3
10-21
Hazard Note Corrosive
HazardClass 8
PackingGroup II
HS Code 29171900
MSDS Information
ProviderLanguage
Ethyl (chloroformyl)acetate English
SigmaAldrich English
ACROS English
ALFA English
Ethyl malonyl chloride Usage And Synthesis
Chemical Propertiesclear yellow to brown liquid
UsesEmployed in the synthesis of 3-pyrrolin-2-ones via amidation with propargylamines and subsequent base catalyzed 5-exo-dig cyclization.1
UsesEthyl malonyl chloride is used in the syntheses of methanofullerodendimers and 3-pyrrolin-2-ones. It plays a vital role in the preparation of 3,5-disubstituted 1,2,4-oxadiazole derivatives, which are potential peptidomimetic building blocks. It is a versatile acylating agent for propargyl alcohols, hydrazines and amines.
General DescriptionEthyl malonyl chloride is a versatile acylating agent for propargyl alcohols, hydrazines and amines.
Ethyl malonyl chloride Preparation Products And Raw materials
Preparation Products7-FLUORO-3,4-DIHYDRO-6-NITRO-3-OXOQUINOXALINE-2-CARBOXYLIC ACID-->2,3,4,5-Tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one-->5,6-DIHYDRO-4-(2-METHYL-2-PHENYLHYDRAZINO)-2-1H-PYRIDINONE-->2,4-Piperadinedione-->TERT-BUTYL ETHYL MALONATE-->4-Pyridazinecarboxylic acid, 2,3-dihydro-5-hydroxy-2-(3-methylbutyl)-3-oxo-6-(2-thienyl)-, ethyl ester-->ethyl 3-[(5-chloro-2-nitrophenyl)phenylamino]-3-oxopropionate
Ethyl propionylacetate Magnesium acetate Ethanol Ethylbenzene Ethylparaben Cellulose acetate CHLOROETHANE Ethyl cellulose Butyl acetate Ethyl bromoacetate Isopropyl acetate ACETATE Ethyl acetate Epichlorohydrin Ammonium acetate Ethyl malonyl chloride 2-​[[(2-​ethylphenyl)​(2-​hydroxyethyl)​amino]​methyl]​-​3,​3-​difluoro-Propanenitrile S-(hydrogen malonyl)coenzyme A

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