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| | (±)10-HDoHE Basic information |
| Product Name: | (±)10-HDoHE | | Synonyms: | (±)10-HDHA;DDCYKEYDTGCKAS-SKSHMZPZSA-N;4,7,11,13,16,19-Docosahexaenoic acid, 10-hydroxy-, (4Z,7Z,11E,13Z,16Z,19Z)- | | CAS: | 90780-50-0 | | MF: | C22H32O3 | | MW: | 344.49 | | EINECS: | | | Product Categories: | | | Mol File: | 90780-50-0.mol |  |
| | (±)10-HDoHE Chemical Properties |
| Boiling point | 511.2±50.0 °C(Predicted) | | density | 0.995±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml | | pka | 4.58±0.10(Predicted) |
| | (±)10-HDoHE Usage And Synthesis |
| Description | (±)10-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.1,2 It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.3,4,5 (±)10-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. | | References | 1. VanRollins, M., and Murphy, R.C. Autooxidation of docosahexaenoic acid: Analysis of ten isomers of hydroxydocosahexaenoate J. Lipid Res. 25(5),507-517(1984).
2. Reynaud, D., Thickitt, C.P., and Pace-Asciak, C.R. Facile preparation and structural determination of monohydroxy derivatives of docosahexaenoic acid (HDoHE) by α-tocopherol-directed autoxidation Anal. Biochem. 214(1),165-170(1993).
3. VanRollins, M., Baker, R.C., Sprecher, H., et al. Oxidation of docosahexaenoic acid by rat liver microsomes J. Biol. Chem. 259(9),5776-5783(1984).
4. Yamane, M., Abe, A., and Yamane, S. High-performance liquid chromatography-thermospray mass spectrometry of epoxy polyunsaturated fatty acids and epoxyhydroxy polyunsaturated fatty acids from an incubation mixture of rat tissue homogenate J. Chromatogr. 652(2),123-136(1994).
5. Kim, H.Y., Karanian, J.W., Shingu, T., et al. Sterochemical analysis of hydroxylated docosahexaenoates produced by human platelets and rat brain homogenate Prostaglandins 40(5),473-490(1990). |
| | (±)10-HDoHE Preparation Products And Raw materials |
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