ChemicalBook Product Catalog Analytical Chemistry Standard Analytical Standards 2,5-DiMethyl Celecoxib

2,5-DiMethyl Celecoxib

2,5-DiMethyl Celecoxib Basic information
Product Name:2,5-DiMethyl Celecoxib
Synonyms:4-[5-(2,5-DiMethylphenyl)-3-(trifluoroMethyl)-1H-pyrazol-1-yl]benzenesulfonaMide;2,5-DiMethyl-celecoxib DMC;2,5-Dimethylcelecoxib 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide;2,5-DiMethyl Celecoxib;4-[5-(2,5-Dimethyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide;Celecoxib-13;Celecoxib Impurity 42;Celecoxib Impurity K
CAS:457639-26-8
MF:C18H16F3N3O2S
MW:395.4
EINECS:
Product Categories:Amines;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:457639-26-8.mol
2,5-DiMethyl Celecoxib Structure
2,5-DiMethyl Celecoxib Chemical Properties
Melting point >138°C (dec.)
Boiling point 516.7±60.0 °C(Predicted)
density 1.40±0.1 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: soluble20mg/mL, clear
pka9.67±0.10(Predicted)
form powder
color white to beige
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany 3
MSDS Information
2,5-DiMethyl Celecoxib Usage And Synthesis
UsesA non-cyclooxygenase-2 inhibitor analog of Celecoxib (C251000). The celecoxib analog, 2,5-di-Me celecoxib (DMC), lacks COX-2 inhibitory activity but exhibits cytotoxic properties comparable to the COX-2 inhibitor Celecoxib.
Uses2,5-Dimethyl-celecoxib has been used
  • To block the synthesis of prostaglandin E2 and to study effect of transforming growth factor-2 signaling towards cyclooxygenase-2 expression.
  • In an in vitro study to analyze its pro-oxidative capacities in metastatic melanoma/ breast cancer cells.
  • To study its interaction between silymarin on chemically induced osteoarthritis in rats.

Biochem/physiol ActionsCelecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.
storageRoom temperature
2,5-DiMethyl Celecoxib Preparation Products And Raw materials
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