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| Product Name: | YM155 | | Synonyms: | YM155;4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide;SepantroniuM broMide;SepantroniuM broMide(YM155,YM-155);Sepantronium Bromide (YM155);1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-, bromide (1:1);4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide YM 155;YM 155
4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide | | CAS: | 781661-94-7 | | MF: | C20H19BrN4O3 | | MW: | 443.29386 | | EINECS: | | | Product Categories: | Inhibitors;Antineoplastic;apis;Inhibitor | | Mol File: | 781661-94-7.mol |  |
| | YM155 Chemical Properties |
| Melting point | >180°C (dec.) | | storage temp. | -20° | | solubility | Soluble in DMSO (up to 25 mg/ml). | | form | solid | | color | Tan to yellow | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| | YM155 Usage And Synthesis |
| Description | YM-155 (781661-94-7) is a novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members.1?Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer.2?Induces DNA damage.3?YM-155 induces an autophagy-dependent cell death in adenoid cystic carcinoma cells.4 | | Uses | YM155 is a potent IAP (inhibitor of apoptosis proteins) inhibitor for survivin with IC50 of 0.54 nM. | | Uses | YM155 is a novel small-molecule survivin suppressant that suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC cell lines. | | Uses | YM155 is a novel small-molecule survivin suppressant that suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC. cell lines. Potent Survivin Inhibitor. | | Definition | ChEBI: Sepantronium bromide is an organic bromide salt consisting of sepantronium cations and bromide anions. It has been found to selectively inhibit survivin (BIRC5) gene promoter activity and to down-regulate survivin in vitro, so leading to induction of apoptosis. It has a role as an antineoplastic agent, a survivin suppressant and an apoptosis inducer. It contains a sepantronium. | | target | Survivin | | storage | Store at -20°C | | References | 1) Nakahara?et al. (2007),?YM155, a novel small-molecule surviving suppressant, induces regression of established human hormone-refractory prostate tumor xenografts; Cancer Res.?67?8014
2) Okamoto?et al. (2012),?Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin; Mol.Cancer Ther.?11?204
3) Glaros?et al. (2012),?The ‘survivin suppressants’ NSC 80467 and YM 155 induce a DNA damage response; Cancer Chemother. Pharmacol.?70?207
4) Wang?et al. (2014),?Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma; Apoptosis?19?748 |
| | YM155 Preparation Products And Raw materials |
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