ChemicalBook Product Catalog Pharmaceutical intermediates Bulk Drug Intermediates 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-

1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-

1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- Basic information
Uses
Product Name:1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-
Synonyms:1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-;(S)-2-((2-oxo-3-(4-(3-oxoMorpholino)phenyl)oxazolidin-5-yl)Methyl)isoindoline-1,3-dione;2-({(5S)-2-oxo-3-[4-(3-oxoMorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}Methyl)-1H-isoindole-1,3(2H)-dione;RivaroxabanInterMediates-01;4-[4-[(5S)-5-PhthaliMidoMethyl-2-oxo-3-oxazolidinyl]phenyl]-3-Morpholinone;2-[[(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-1H-isoindole-1,3(2H)-dione;Rivaroxaban Intermediate5;Rivaroxaban Phthalimido Impurity
CAS:446292-08-6
MF:C22H19N3O6
MW:421.4
EINECS:610-201-0
Product Categories:Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Intermediate of Rivaroxaban
Mol File:446292-08-6.mol
1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- Structure
1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- Chemical Properties
Melting point 213-215°C
Boiling point 702.9±55.0 °C(Predicted)
density 1.465±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka0.99±0.20(Predicted)
form Solid
color White to Off-White
Water Solubility 12mg/L at 20℃
LogP-0.2 at 25℃
Safety Information
MSDS Information
1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- Usage And Synthesis
Uses

1H-isoindole-1,3(2H)-dione, 2-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]- is an important intermediate for the synthesis of rivaroxaban, which is an anticoagulant and the first orally active direct factor Xa inhibitor.

Chemical PropertiesWhite Solid
UsesRivaroxaban intermediate.
Flammability and ExplosibilityNonflammable
1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- Preparation Products And Raw materials
5-R-Rivaroxaban 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]- 2-ThiophenecarboxaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- AcetaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- m-(Trifluoromethyl)phenylacetic acid 5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- Ethyl (R)-(-)-4-cyano-3-hydroxybutyate 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl 4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)aMino)phenyl]Morpholin-3-one (S)-(+)-GLYCIDYL PHTHALIMIDE 4-(4-NITROPHENYL)MORPHOLIN-3-ONE (S)-(+)-Epichlorohydrin 1,2-Cyclohexanedione POLYSTYRENE IODOSOACETATE Rivaroxaban
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